The whole-genome molecular epidemiology of sequential isolates of Acinetobacter baumannii colonizing the rectum of patients in an adult intensive care unit of a tertiary hospital.

Autor:	Bulach D; Microbiological Diagnostic Unit Public Health Laboratory, Peter Doherty Institute for Infection and Immunity, The University of Melbourne , Melbourne, Victoria, Australia.; Melbourne Bioinformatics, The University of Melbourne , Carlton, Victoria, Australia., Carter GP; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne , Melbourne, Victoria, Australia., Li L; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne , Melbourne, Victoria, Australia., Al-Hashem G; Department of Microbiology, College of Medicine, Kuwait University , Jabriya, Kuwait., Rotimi VO; Department of Microbiology, College of Medicine, Kuwait University , Jabriya, Kuwait., Albert MJ; Department of Microbiology, College of Medicine, Kuwait University , Jabriya, Kuwait.
Jazyk:	angličtina
Zdroj:	Microbiology spectrum [Microbiol Spectr] 2023 Dec 12; Vol. 11 (6), pp. e0219123. Date of Electronic Publication: 2023 Oct 16.
DOI:	10.1128/spectrum.02191-23
Abstrakt:	Importance: Acinetobacter baumannii is a multidrug-resistant nosocomial pathogen that colonizes and infects debilitated patients in the ICU. There is very little information on the genomic characteristics of colonizing strains. This information is important to understand the evolution of lineages of A. baumannii that develop resistance while patients receive antibiotic treatment in the ICU. Our study demonstrated different patterns of colonization of the rectum of ICU patients with different STs of A. baumannii while one ST colonized all patients. Some STs carried more antibiotic resistance genes compared to others. However, there was a correlation between ST and a particular resistance gene profile. Our results further elucidate the dynamics of enteric colonization of this opportunistic pathogen. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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