The Stiff Joint: Comparative Evaluation of Monotherapy and Combination Therapy With Urate Lowering Agents in Managing Acute Gout.

Autor:	Okobi OE; Family Medicine, Larkin Community Hospital Palm Springs Campus, Miami, USA.; Family Medicine, Medficient Health Systems, Laurel, Maryland, USA.; Family Medicine, Lakeside Medical Center, Belle Glade, USA., Oletu H; Medicine and Surgery, University of Benin, Benin City, NGA.; Public Health, University of Wolverhampton, Wolverhampton, GBR., Chukwuedozie-Echeazu AB; General Practice, Ebonyi State University, Ebonyi, NGA.; General Practice, University of Lagos, Lagos, NGA., Keke VC; Internal Medicine, University of Nigeria, Enugu, NGA., Nwachukwu OB; Neurosciences and Psychology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.; Family Medicine, American International School of Medicine Georgetown, Guyana, USA., Akunne HS; Internal Medicine, Delta State University, Abraka, NGA., Ekpemiro CU; Surgery, Federal Medical Centre, Umuahia, NGA., Oranika US; Family Medicine, University of Alberta Hospital, Edmonton, CAN., Akueme NT; Dermatology, University of Medical Sciences (UNIMEDTH), Ondo State, NGA., Akanle OE; General Practice, Nisa Premier Hospital, Abuja, NGA., Ogbuagu BC; Family Medicine, Deer Ridge Family Clinic (DRFC), Calgary, CAN., Mbah LA; Primary Care, Veterans Affairs, Fortwayne, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2023 Sep 12; Vol. 15 (9), pp. e45087. Date of Electronic Publication: 2023 Sep 12 (Print Publication: 2023).
DOI:	10.7759/cureus.45087
Abstrakt:	Gout, an extremely painful form of arthritis, is triggered by the innate immune system's response to the accumulation of monosodium urate crystals in specific joints and surrounding tissues. This condition is characterized by recurring episodes of excruciating arthritis flares, interspersed with periods of disease quiescence. Over time, gout can result in disability, tophi formation, and severe pain. The treatment of gout is centered around two main objectives: alleviating inflammation and pain during acute gout attacks and long-term management to reduce serum urate levels and mitigate the risk of future attacks. Addressing inflammation and pain during acute attacks is often complicated by various factors, including underlying health conditions commonly associated with gout, such as hypertension, chronic kidney disease, cardiovascular disease, and diabetes mellitus. Moreover, gout patients are frequently older and have multiple coexisting health issues, necessitating complex medication regimens. Given the rising prevalence of gout and its associated comorbidities, there's a growing demand for improved treatment options. While existing treatments effectively manage gout in some patients, a significant portion, particularly those with comorbidities, face contraindications to these treatments and require alternative approaches. Innovative medications are required to enhance gout treatment, especially for individuals with concurrent health conditions. These considerations underscore the importance of reviewing both monotherapy and combination therapy approaches for acute gout treatment. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Okobi et al.)
Databáze:	MEDLINE
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