Macrophage Membrane-Camouflaged Aggregation-Induced Emission Nanoparticles Enhance Photodynamic-Immunotherapy to Delay Postoperative Tumor Recurrence.

Autor: Meng Z; Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, 430074, P. R. China., Wang T; Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, 430074, P. R. China., Hu Y; Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, 430074, P. R. China., Ouyang H; Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, 430074, P. R. China., Wang Q; Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, 430074, P. R. China., Wu M; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430034, P. R. China., Zhou J; College of Material, Chemistry and Chemical Engineering, Hangzhou, Normal University, Hangzhou, 311121, P. R. China., Lou X; Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, 430074, P. R. China.; Zhejiang Institute, China University of Geosciences, Hangzhou, 311305, P. R. China., Wang S; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430034, P. R. China., Dai J; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430034, P. R. China., Xia F; Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, 430074, P. R. China.; Zhejiang Institute, China University of Geosciences, Hangzhou, 311305, P. R. China.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2024 Feb; Vol. 13 (4), pp. e2302156. Date of Electronic Publication: 2023 Nov 02.
DOI: 10.1002/adhm.202302156
Abstrakt: Surgery is a traditional tumor treatment, and immunotherapy can reduce the postoperative recurrence of tumors. However, the intrinsic limits of low responsive rate and non-tumor specificity of immunotherapy agents are still insufficient to address therapeutic demands. Herein, the macrophages membrane camouflaged nanoparticles (NPs), named M@PFC, consisting of the aggregation-induced emission photosensitizer (PF3-PPh 3 ) and immune adjuvant (CpG), are reported. As the protein on the membrane interacts with the vascular cell adhesion molecule 1 (VCAM-1) of cancer cells, M@PFC efficiently transports CpG to the tumor. Meanwhile, M@PFC can evade clearance by the immune system and prolong the circulation time in vivo; thus, enhancing their accumulation in tumors. PF3-PPh 3 promotes high production of reactive oxygen species (ROS) and triggers immune cell death (ICD) in tumor cells under light exposure. Importantly, CpG enrichment in tumors can stimulate tumor cells to produce immune factors to assist in enhancing ICD effects. The synergistic effect combining the PDT properties of the aggregation-induced emission (AIE)-active photosensitizer and immunotherapy properties of CpG significantly delays tumor recurrence after surgery. In conclusion, this strategy achieves the synergistic activation of the immune system for anti-tumor activity, providing a novel paradigm for the development of therapeutic nanodrugs to delay postoperative tumor recurrence.
(© 2023 Wiley-VCH GmbH.)
Databáze: MEDLINE
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