Production, isolation, and shipment of clinically relevant quantities of astatine-211: A simple and efficient approach to increasing supply.
| Autor: | McIntosh LA; Cyclotron Institute, Texas A&M University, College Station, TX 77843, USA. Electronic address: lmcintosh@tamu.edu., Burns JD; Chemistry Department, The University of Alabama at Birmingham, Birmingham, AL 35924, USA. Electronic address: burnsjon@uab.edu., Tereshatov EE; Cyclotron Institute, Texas A&M University, College Station, TX 77843, USA., Muzzioli R; Department of Cancer System Imaging, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Hagel K; Cyclotron Institute, Texas A&M University, College Station, TX 77843, USA., Jinadu NA; Chemistry Department, The University of Alabama at Birmingham, Birmingham, AL 35924, USA., McCann LA; Cyclotron Institute, Texas A&M University, College Station, TX 77843, USA; Chemistry Department, Texas A&M University, College Station, TX 77843, USA., Picayo GA; Cyclotron Institute, Texas A&M University, College Station, TX 77843, USA; Chemistry Department, Texas A&M University, College Station, TX 77843, USA., Pisaneschi F; Department of Cancer System Imaging, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for Translational Cancer Research, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases (IMM) at The University of Texas Health Science Center at Houston, USA., Piwnica-Worms D; Department of Cancer System Imaging, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Schultz SJ; Cyclotron Institute, Texas A&M University, College Station, TX 77843, USA; Chemistry Department, Texas A&M University, College Station, TX 77843, USA., Tabacaru GC; Cyclotron Institute, Texas A&M University, College Station, TX 77843, USA., Abbott A; Cyclotron Institute, Texas A&M University, College Station, TX 77843, USA; Chemistry Department, Texas A&M University, College Station, TX 77843, USA., Green B; Cyclotron Institute, Texas A&M University, College Station, TX 77843, USA; Chemistry Department, Texas A&M University, College Station, TX 77843, USA., Hankins T; Cyclotron Institute, Texas A&M University, College Station, TX 77843, USA; Chemistry Department, Texas A&M University, College Station, TX 77843, USA., Hannaman A; Cyclotron Institute, Texas A&M University, College Station, TX 77843, USA; Chemistry Department, Texas A&M University, College Station, TX 77843, USA., Harvey B; Cyclotron Institute, Texas A&M University, College Station, TX 77843, USA; Physics Department, Texas A&M University, College Station, TX 77843, USA., Lofton K; Cyclotron Institute, Texas A&M University, College Station, TX 77843, USA; Chemistry Department, Texas A&M University, College Station, TX 77843, USA., Rider R; Cyclotron Institute, Texas A&M University, College Station, TX 77843, USA; Chemistry Department, Texas A&M University, College Station, TX 77843, USA., Sorensen M; Cyclotron Institute, Texas A&M University, College Station, TX 77843, USA; Chemistry Department, Texas A&M University, College Station, TX 77843, USA., Tabacaru A; Cyclotron Institute, Texas A&M University, College Station, TX 77843, USA., Tobin Z; Cyclotron Institute, Texas A&M University, College Station, TX 77843, USA; Chemistry Department, Texas A&M University, College Station, TX 77843, USA., Yennello SJ; Cyclotron Institute, Texas A&M University, College Station, TX 77843, USA; Chemistry Department, Texas A&M University, College Station, TX 77843, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Nuclear medicine and biology [Nucl Med Biol] 2023 Nov-Dec; Vol. 126-127, pp. 108387. Date of Electronic Publication: 2023 Sep 21. |
| DOI: | 10.1016/j.nucmedbio.2023.108387 |
| Abstrakt: | The alpha emitter astatine-211 ( 211 At) is a promising candidate for cancer treatment based on Targeted Alpha (α) Therapy (TAT). A small number of facilities, distributed across the United States, are capable of accelerating α-particle beams to produce 211 At. However, challenges remain regarding strategic methods for shipping 211 At in a form adaptable to advanced radiochemistry reactions and other uses of the radioisotope. Purpose: Our method allows shipment of 211 At in various quantities in a form convenient for further radiochemistry. Procedures: For this study, a 3-octanone impregnated Amberchrom CG300M resin bed in a column cartridge was used to separate 211 At from the bismuth matrix on site at the production accelerator (Texas A&M) in preparation for shipping. Aliquots of 6 M HNO Main Findings: Air-dried column hold times of various lengths did not inhibit simple and efficient recovery of 211 At. Solution eluted from the column was sufficiently high in specific activity to successfully radiolabel a model compound, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (1), with 211 At. The method to prepare and ship 211 At described in this manuscript has also been used to ship larger quantities of 211 At a greater distance to University of Alabama at Birmingham. Principal Conclusions: The successful proof of this method paves the way for the distribution of 211 At from Texas A&M University to research institutions and clinical oncology centers in Texas and elsewhere. Use of this simple method at other facilities has the potential increase the overall availability of 211 At for preclinical and clinical studies. Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: The authors declare the following competing financial interest(s): J.D.B., E.E.T., L.A. McIntosh, G.C.T., S.J.Y. have patent #PCT/US21/25156 Rapid At-211 purification method and E.E.T., J.D.B., L.A. McIntosh, G.C.T., S.J.Y. have patent #PCT/US21/63241 Systems and Methods for Automated Separation and Recovery of Astatine pending to Texas A&M University. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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