The role of gut-brain axis in a rotenone-induced rat model of Parkinson's disease.

Autor: Dos Santos JCC; Medical School of the Christus University Center-UNICHRISTUS, Fortaleza, CE, Brazil; Graduate Program in Morphofunctional Sciences, Federal University of Ceará-UFC, Fortaleza, CE, Brazil. Electronic address: julio.santos@alu.ufc.br., Rebouças CDSM; Graduate Program in Morphofunctional Sciences, Federal University of Ceará-UFC, Fortaleza, CE, Brazil; Morphology Department of the Federal University of Ceará-UFC, Fortaleza, CE, Brazil., Oliveira LF; Catholic University of Brasília-UCB, Brasília, DF, Brazil., Cardoso FDS; Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, School of Medicine of Ribeirão Preto of the University of São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil; Hospital do Câncer de Muriaé, Fundação Cristiano Varella (FCV), Muriaé, MG, Brazil., Nascimento TS; Physiology and Pharmacology Department of the Federal University of Ceará-UFC, Fortaleza, CE, Brazil., Oliveira AV; Physiology and Pharmacology Department of the Federal University of Ceará-UFC, Fortaleza, CE, Brazil., Lima MPP; Medical School of the Christus University Center-UNICHRISTUS, Fortaleza, CE, Brazil., de Andrade GM; Physiology and Pharmacology Department of the Federal University of Ceará-UFC, Fortaleza, CE, Brazil., de Castro Brito GA; Morphology Department of the Federal University of Ceará-UFC, Fortaleza, CE, Brazil; Physiology and Pharmacology Department of the Federal University of Ceará-UFC, Fortaleza, CE, Brazil., de Barros Viana GS; Physiology and Pharmacology Department of the Federal University of Ceará-UFC, Fortaleza, CE, Brazil.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2023 Dec; Vol. 132, pp. 185-197. Date of Electronic Publication: 2023 Jul 13.
DOI: 10.1016/j.neurobiolaging.2023.07.005
Abstrakt: Parkinson's disease (PD) is a widespread neurodegenerative condition affecting millions globally. This investigation centered on the gut-brain axis in a rotenone-induced PD rat model. Researchers monitored behavioral shifts, histological modifications, neurodegeneration, and inflammation markers throughout the rats' bodies. Results revealed that rotenone-treated rats displayed reduced exploration (p = 0.004) and motor coordination (p < 0.001), accompanied by decreased Nissl staining and increased alpha-synuclein immunoreactivity in the striatum (p = 0.009). Additionally, these rats exhibited weight loss (T3, mean = 291.9 ± 23.67; T19, mean = 317.5 ± 17.53; p < 0.05) and substantial intestinal histological alterations, such as shortened villi, crypt architecture loss, and inflammation. In various regions, researchers noted elevated immunoreactivity to ionized binding adapter molecule (IBA)-1 (p < 0.05) and reduced immunoreactivity to glial fibrillary acidic protein (p < 0.05) and S100B (p < 0.001), indicating altered glial cell activity. Overall, these findings imply that PD is influenced by gut-brain axis changes and may originate in the intestine, impacting bidirectional gut-brain communication.
Competing Interests: Disclosure statement The authors declare that they have no conflicts of interest. All authors read and approved the final manuscript.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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