| Autor: |
Roos VC; Laboratório de Pesquisa em Microbiologia Oral - LAPEMICRO, UFSM, Santa Maria, Rio Grande do Sul, Brazil., Denardi LB; Laboratório de Pesquisas Micológicas - LAPEMI, UFSM, Santa Maria, Rio Grande do Sul, Brazil., Teixeira CA; Laboratório de Pesquisa em Microbiologia Oral - LAPEMICRO, UFSM, Santa Maria, Rio Grande do Sul, Brazil., Machado VS; Laboratório de Pesquisa em Microbiologia Oral - LAPEMICRO, UFSM, Santa Maria, Rio Grande do Sul, Brazil., Verdi CM; Laboratório de Pesquisa em Microbiologia Oral - LAPEMICRO, UFSM, Santa Maria, Rio Grande do Sul, Brazil., Dos Santos ID; Núcleo Integrado de Desenvolvimento em Análises Laboratoriais - NIDAL, UFSM, Santa Maria, Rio Grande do Sul, Brazil., Wagner R; Núcleo Integrado de Desenvolvimento em Análises Laboratoriais - NIDAL, UFSM, Santa Maria, Rio Grande do Sul, Brazil., Sagrillo MR; Laboratório de Cultivo Celular, Programa de Pós-graduação em Nanociências - UFN, Santa Maria, Rio Grande do Sul, Brazil., Pacheco PDS; Laboratório de Plantas Medicinais - LABPLAM, URI, Santiago, Rio Grande do Sul, Brazil., Gindri AL; Laboratório de Plantas Medicinais - LABPLAM, URI, Santiago, Rio Grande do Sul, Brazil., Santos RCV; Laboratório de Pesquisa em Microbiologia Oral - LAPEMICRO, UFSM, Santa Maria, Rio Grande do Sul, Brazil. |
| Abstrakt: |
The leaves of Citrus deliciosa Tenore were collected in southern Brazil, dried, and subjected to the hydrodistillation process to obtain the essential oil. The extraction of essential oil yielded 0.97% ± 0.04. The chromatographic profile of this compound revealed 11 substances, being methyl N-methyl-anthranilate (75.1%), γ-terpinene (13.8%), and Limonene (7%) as major substances. The essential oil shows antifungal action against all tested yeasts, with promising action against Cryptococcus neoformans, Cryptococcus gattii, and Trichosporon asahii . This compound was also able to inhibit the biofilm production of Candida albicans, Candida glabrata, Candida parapsilosis, and T. asahii . The essential oil of tangerine showed weak antioxidant action. It did not show cytotoxicity in human mononuclear cells. It is hoped that these results may guide future studies for the production of formulations that can be used in the treatment of biofilms caused by yeasts, as well as in candidiasis, cryptococcosis, and/or trichosporonosis. |
