| Autor: |
Leser B; Department of Psychology, University of Graz, 8010 Graz, Austria., Dalkner N; Department of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, Austria., Tmava-Berisha A; Department of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, Austria., Fellendorf FT; Department of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, Austria., Unterrainer HF; Faculty of Psychotherapy Science, Sigmund Freud University, 1020 Vienna, Austria., Stross T; Department of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, Austria., Maget A; Department of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, Austria., Platzer M; Department of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, Austria., Bengesser SA; Department of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, Austria., Häussl A; Department of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, Austria., Zwigl I; Department of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, Austria., Birner A; Department of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, Austria., Queissner R; Department of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, Austria., Stix K; Department of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, Austria., Wels L; Department of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, Austria., Schönthaler EMD; Department of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, Austria., Lenger M; Department of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, Austria., Schwerdtfeger AR; Department of Psychology, University of Graz, 8010 Graz, Austria., Zelzer S; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, Austria., Herrmann M; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, Austria., Reininghaus EZ; Department of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, Austria. |
| Abstrakt: |
Recent evidence on the association between vitamin D and cognition in mentally healthy individuals is inconsistent. Furthermore, the link between vitamin D and cognitive ability in individuals with bipolar disorder has not been studied yet. Thus, we aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D), 24,25 dihydroxyvitamin D (24,25(OH)2D, the vitamin D metabolite ratio (VMR) and cognition in a cohort of euthymic patients with bipolar disorder. Vitamin D metabolites were measured simultaneously by liquid-chromatography tandem mass-spectrometry in serum samples from 86 outpatients with bipolar disorder and 93 healthy controls. Neither the inactive precursor 25(OH)D, nor the primary vitamin D catabolite 24,25(OH)2D, or the vitamin D metabolite ratio were significantly associated with the domains "attention", "memory", or "executive function" in individuals with bipolar disorder and healthy controls. Further, no vitamin D deficiency effect or interaction group × vitamin D deficiency was found in the cognitive domain scores. In summary, the present study does not support vitamin D metabolism as a modulating factor of cognitive function in euthymic BD patients. Considering the current study's cross-sectional design, future research should expand these results in a longitudinal setting and include additional aspects of mental health, such as manic or depressive symptoms, long-term illness course and psychopharmacological treatment. |
