| Autor: |
Bou-Maroun E; PAM UMR A 02.102, Food and Microbiological Processes, Institut Agro, Université Bourgogne Franche-Comté, 1 Esplanade Erasme, F-21000 Dijon, France., Dahbi L; Derttech 'Packtox', NUTOX, INSERM U1231, Université Bourgogne Franche-Comté, F-21000 Dijon, France., Dujourdy L; Institut Agro Dijon, Service d'Appui à la Recherche, F-21000 Dijon, France., Ferret PJ; Safety Assessment Department, Pierre Fabre Dermo-Cosmétique, 3 Avenue Hubert Curien, 31035 Toulouse, France., Chagnon MC; Derttech 'Packtox', NUTOX, INSERM U1231, Université Bourgogne Franche-Comté, F-21000 Dijon, France. |
| Jazyk: |
angličtina |
| Zdroj: |
Polymers [Polymers (Basel)] 2023 Oct 06; Vol. 15 (19). Date of Electronic Publication: 2023 Oct 06. |
| DOI: |
10.3390/polym15194009 |
| Abstrakt: |
The endocrine activity and endocrine disruptor (ED) chemical profiles of eleven plastic packaging materials covering five major polymer types (3PET, 1HDPE, 4LDPE, 2 PP, and 1SAN) were investigated using in vitro cell-based reporter-gene assays and a non-targeted chemical analysis using gas chromatography coupled to mass spectrometry (GC-MS). To mimic cosmetic contact, six simulants (acidic, alkaline, neutral water, ethanol 30%, glycerin, and paraffin) were used in migration assays performed by filling the packaging with simulant. After 1 month at 50 °C, simulants were concentrated by Solid Phase Extraction (SPE) or Liquid-Liquid Extraction (LLE). The migration profiles of seven major endocrine disrupting chemicals detected from GC-MS in the different materials and simulants were compared with Estrogen Receptor (ER) and Androgen Receptor (AR) activities. With low extraction of ED chemicals in aqueous simulants, no endocrine activities were recorded in the leachates. Paraffin was shown to be the most extracting simulant of antiandrogenic chemicals, while glycerin has estrogenic activities. Overall, ED chemical migration in paraffin was correlated with hormonal activity. The NIAS 2,4-di-tert-butyl phenol and 7,9-di-tert-butyl1-oxaspiro (4,5) deca-6,9-diene-2,8-dione were two major ED chemicals present in all polymers (principally in PP and PE) and in the highest quantity in paraffin simulant. The use of glycerin and liquid paraffin as cosmetic product simulants was demonstrated to be relevant and complementary for the safety assessment of released compounds with endocrine activities in this integrated strategy combining bioassays and analytical chemistry approaches. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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