Hospital Admission Factors Independently Affecting the Risk of Mortality of COVID-19 Patients.

Autor: Paciorek M; Department of Adults' Infectious Diseases, Medical University of Warsaw, 02-001 Warsaw, Poland.; Hospital for Infectious Diseases in Warsaw, 01-201 Warsaw, Poland., Bieńkowski C; Department of Adults' Infectious Diseases, Medical University of Warsaw, 02-001 Warsaw, Poland.; Hospital for Infectious Diseases in Warsaw, 01-201 Warsaw, Poland., Kowalska JD; Department of Adults' Infectious Diseases, Medical University of Warsaw, 02-001 Warsaw, Poland.; Hospital for Infectious Diseases in Warsaw, 01-201 Warsaw, Poland., Skrzat-Klapaczyńska A; Department of Adults' Infectious Diseases, Medical University of Warsaw, 02-001 Warsaw, Poland.; Hospital for Infectious Diseases in Warsaw, 01-201 Warsaw, Poland., Bednarska A; Department of Adults' Infectious Diseases, Medical University of Warsaw, 02-001 Warsaw, Poland.; Hospital for Infectious Diseases in Warsaw, 01-201 Warsaw, Poland., Krogulec D; Department of Adults' Infectious Diseases, Medical University of Warsaw, 02-001 Warsaw, Poland.; Hospital for Infectious Diseases in Warsaw, 01-201 Warsaw, Poland., Cholewińska G; Hospital for Infectious Diseases in Warsaw, 01-201 Warsaw, Poland.; Department of Infectious Diseases, Collegium Medicum, Cardinal Stefan Wyszynski University in Warsaw, 01-815 Warsaw, Poland., Kowalski J; Hospital for Infectious Diseases in Warsaw, 01-201 Warsaw, Poland.; Department of Infectious Diseases, Collegium Medicum, Cardinal Stefan Wyszynski University in Warsaw, 01-815 Warsaw, Poland., Podlasin R; Hospital for Infectious Diseases in Warsaw, 01-201 Warsaw, Poland.; Department of Infectious Diseases, Collegium Medicum, Cardinal Stefan Wyszynski University in Warsaw, 01-815 Warsaw, Poland., Ropelewska-Łącka K; Hospital for Infectious Diseases in Warsaw, 01-201 Warsaw, Poland.; Department of Infectious Diseases, Collegium Medicum, Cardinal Stefan Wyszynski University in Warsaw, 01-815 Warsaw, Poland., Wasilewski P; Hospital for Infectious Diseases in Warsaw, 01-201 Warsaw, Poland.; Department of Infectious Diseases, Collegium Medicum, Cardinal Stefan Wyszynski University in Warsaw, 01-815 Warsaw, Poland., Boros PW; Lung Pathophysiology Department, National TB & Lung Diseases Research Institute, 01-138 Warsaw, Poland., Martusiewicz-Boros MM; 3rd Lung Diseases & Oncology Department, National TB & Lung Diseases Research Institute, 01-138 Warsaw, Poland., Pulik P; Hospital for Infectious Diseases in Warsaw, 01-201 Warsaw, Poland., Pihowicz A; Hospital for Infectious Diseases in Warsaw, 01-201 Warsaw, Poland., Horban A; Department of Adults' Infectious Diseases, Medical University of Warsaw, 02-001 Warsaw, Poland.; Hospital for Infectious Diseases in Warsaw, 01-201 Warsaw, Poland.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2023 Sep 28; Vol. 12 (19). Date of Electronic Publication: 2023 Sep 28.
DOI: 10.3390/jcm12196264
Abstrakt: Introduction: COVID-19 is a disease characterized by high in-hospital mortality, which seems to be dependent on many predisposing factors.
Objectives: The aim of this study was to analyze the clinical symptoms, abnormalities in the results of laboratory tests, and coexisting chronic diseases that independently affected the risk of in-hospital mortality in patients with COVID-19.
Patients and Methods: We analyzed the records of patients with COVID-19 who were hospitalized from 6 March 2020 to 30 November 2021.
Results: Out of the entire group of 2138 patients who were analyzed, 12.82% died during hospitalization. In-hospital mortality was independently associated with older age (OR 1.53, 95% CI 1.20-1.97); lower arterial blood oxygen saturation (OR 0.95, 95% CI 0.92-0.99); the presence of a neoplasm (OR 4.45, 95% CI 2.01-9.62), a stomach ulcer (OR 3.35, 95% CI 0.94-11.31), and dementia (OR 3.40, 95% CI 1.36-8.26); a higher score on the SOFA scale (OR 1.73, 95% CI 1.52-1.99); higher lactate dehydrogenase (LDH) (OR 1.08, 95% CI 1.05-1.12); higher N-terminal pro-brain natriuretic peptide (NT pro BNP) (OR 1.06, 95% CI 1.01-1.11); and lower total bilirubin in blood concentration (OR 0.94, 95% CI 0.90-0.99).
Conclusions: We found that low oxygen saturation, old age, and the coexistence of cancer, gastric ulcers, and dementia syndrome were variables that independently increased mortality during hospitalization due to COVID-19. Moreover, we found that decreased platelet count and bilirubin concentration and increased levels of LDH and NT-proBNP were laboratory test results that independently indicated a higher risk of mortality. We also confirmed the usefulness of the SOFA scale in predicting treatment results. The ability to identify mortality risk factors on admission to hospital will facilitate both adjusting the intensity of treatment and the monitoring of patients infected with SARS-CoV-2.
Databáze: MEDLINE
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