| Autor: |
Rybolt TR, Burrell DE, Shults JM, Kelley AK |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of pharmaceutical sciences [J Pharm Sci] 1986 Sep; Vol. 75 (9), pp. 904-6. |
| DOI: |
10.1002/jps.2600750918 |
| Abstrakt: |
The in vitro adsorption and coadsorption of acetaminophen and N-acetylcysteine using simulated gastric (pH 1.2) and intestinal (pH 7.0) conditions were examined for a range of charcoal-to-drug ratios between 1 and 7. Although both substances were adsorbed by the activated carbon, the adsorption of acetaminophen was greater than that of N-acetylcysteine for both acidic and neutral pH conditions. In the coadsorption studies, the acetaminophen was always adsorbed to a greater extent than the N-acetylcysteine. These results agree with previous in vivo studies that suggest that the concomitant use of N-acetylcysteine and activated carbon powder is an appropriate treatment for acetaminophen overdose. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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