Biodegradable Water-Soluble Matrix for Immobilization of Biocidal 4-Hexylresorcinol.

Autor: Novoskoltseva OA; Faculty of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia., Litmanovich EA; Faculty of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia., Loiko NG; Department of Microbiology, Federal Research Center 'Fundamentals of Biotechnology' RAS, 119071 Moscow, Russia., Nikolaev YA; Department of Microbiology, Federal Research Center 'Fundamentals of Biotechnology' RAS, 119071 Moscow, Russia., Yaroslavov AA; Faculty of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2023 Sep 28; Vol. 24 (19). Date of Electronic Publication: 2023 Sep 28.
DOI: 10.3390/ijms241914717
Abstrakt: Biocidal coatings have been used in biomedicine, cosmetology and the food industry. In this article, the coatings are described as being composed of non-stoichiometric polycomplexes, products of electrostatic coupling of two commercial biodegradable ionic polymers, anionic sodium alginate and cationic quaternized hydroxyethyl cellulose ethoxylate. Non-stoichiometric polycomplexes with a 5-fold excess of the cationic polymer were used for immobilizing hydrophobic biocidal 4-hexylresorcinol (HR). Being dispersed in water, the polycomplex particles were capable of absorbing a tenfold excess of HR in relation to the polycation. After deposition onto the plastic surface and drying, the aqueous polycomplex-HR composite formulation forms a transparent homogeneous coating, which swells slightly in water. The interpolyelectrolyte complex (IPEC) is substantially non-toxic. The incorporation of HR in the IPEC imparts antimicrobial activity to the resulting composite, in both aqueous solutions and coatings, against Gram-negative and Gram-positive bacteria and yeast. The polysaccharide-based polycomplexes with embedded HR are promising for the fabrication of biocidal films and coatings.
Databáze: MEDLINE
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