Surface Functionalisation of Self-Assembled Quantum Dot Microlasers with a DNA Aptamer.

Autor: Charlton BK; Technology & Innovation Centre, Institute of Photonics, University of Strathclyde, 99 George Street, Glasgow G1 1RD, UK., Downie DH; Technology & Innovation Centre, Institute of Photonics, University of Strathclyde, 99 George Street, Glasgow G1 1RD, UK., Noman I; Technology & Innovation Centre, Institute of Photonics, University of Strathclyde, 99 George Street, Glasgow G1 1RD, UK., Alves PU; Technology & Innovation Centre, Institute of Photonics, University of Strathclyde, 99 George Street, Glasgow G1 1RD, UK., Eling CJ; Technology & Innovation Centre, Institute of Photonics, University of Strathclyde, 99 George Street, Glasgow G1 1RD, UK., Laurand N; Technology & Innovation Centre, Institute of Photonics, University of Strathclyde, 99 George Street, Glasgow G1 1RD, UK.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2023 Sep 22; Vol. 24 (19). Date of Electronic Publication: 2023 Sep 22.
DOI: 10.3390/ijms241914416
Abstrakt: The surface functionalisation of self-assembled colloidal quantum dot supraparticle lasers with a thrombin binding aptamer (TBA-15) has been demonstrated. The self-assembly of CdSSe/ZnS alloyed core/shell microsphere-shape CQD supraparticles emitting at 630 nm was carried out using an oil-in-water emulsion technique, yielding microspheres with an oleic acid surface and an average diameter of 7.3 ± 5.3 µm. Surface modification of the microspheres was achieved through a ligand exchange with mercaptopropionic acid and the subsequent attachment of TBA-15 using EDC/NHS coupling, confirmed by zeta potential and Fourier transform IR spectroscopy. Lasing functionality between 627 nm and 635 nm was retained post-functionalisation, with oleic acid- and TBA-coated microspheres exhibiting laser oscillation with thresholds as low as 4.10 ± 0.37 mJ·cm -2 and 7.23 ± 0.78 mJ·cm -2 , respectively.
Databáze: MEDLINE
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