Anacaulase-bcdb for the treatment of severe thermal burns.
| Autor: | Shoham Y; Plastic and Reconstructive Surgery Department and Burn Unit, Soroka University Medical Center, Beer Sheba, Israel.; Plastic Surgery Department and Burn Unit, Ben-Gurion University of the Negev Faculty of Health Sciences, Plastic Surgery, Beer-Sheva, Israel., Krieger Y; Plastic and Reconstructive Surgery Department and Burn Unit, Soroka University Medical Center, Beer Sheba, Israel.; Plastic Surgery Department and Burn Unit, Ben-Gurion University of the Negev Faculty of Health Sciences, Plastic Surgery, Beer-Sheva, Israel., Goverman J; Mass General Brigham, Inc. Department of Surgery, Massachusetts General Hospital, Sumner Redstone Burn Center, Harvard Medical School, Boston, MA, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Expert opinion on biological therapy [Expert Opin Biol Ther] 2023 Jul-Dec; Vol. 23 (12), pp. 1185-1191. Date of Electronic Publication: 2023 Dec 28. |
| DOI: | 10.1080/14712598.2023.2270903 |
| Abstrakt: | Introduction: Accurate burn depth assessment and early excision of burn eschar with maximal dermal preservation are key concepts in the optimal care of burn injury. Although excision with knife has long since been standard of care, a newer technique for wound bed preparation utilizing a bromelain-based enzyme has gained popularity worldwide and may offer several advantages. Areas Covered: Here we report the pharmacologic properties, evidence for clinical efficacy, safety, and tolerability of anacaulase-bcdb for the treatment of deep partial thickness and full thickness burns. Expert Opinion: Anacaulase-bcdb is a safe, non-surgical, selective eschar removal agent. It offers advantages over surgical excision of burn with knife and fulfills two unmet needs: burn depth assessment and dermal preservation during excision. Evidence supports a faster time to complete eschar removal; reduced number of operations; reduction in the amount of autografting, length of stay, and blood loss; prevention of burn induced compartment syndrome; and improved cosmetic outcome. |
| Databáze: | MEDLINE |
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