Role of Neurohumoral Imbalance at Post-Traumatic Stress Disorder in the Antitumor Immune Response. Experimental Study.

Autor: Kondashevskaya MV; Avtsyn Research Institute of Human Morphology of the Federal State Budgetary Scientific Institution 'Petrovsky National Research Centre of Surgery', Moscow, Russia. marivladiko@mail.ru., Artemieva KA; Avtsyn Research Institute of Human Morphology of the Federal State Budgetary Scientific Institution 'Petrovsky National Research Centre of Surgery', Moscow, Russia., Aleksankina VV; Avtsyn Research Institute of Human Morphology of the Federal State Budgetary Scientific Institution 'Petrovsky National Research Centre of Surgery', Moscow, Russia., Kudelkina VV; Avtsyn Research Institute of Human Morphology of the Federal State Budgetary Scientific Institution 'Petrovsky National Research Centre of Surgery', Moscow, Russia., Kosyreva AM; Avtsyn Research Institute of Human Morphology of the Federal State Budgetary Scientific Institution 'Petrovsky National Research Centre of Surgery', Moscow, Russia., Areshidze DA; Avtsyn Research Institute of Human Morphology of the Federal State Budgetary Scientific Institution 'Petrovsky National Research Centre of Surgery', Moscow, Russia., Kozlova MA; Avtsyn Research Institute of Human Morphology of the Federal State Budgetary Scientific Institution 'Petrovsky National Research Centre of Surgery', Moscow, Russia., Mikhaleva LM; Avtsyn Research Institute of Human Morphology of the Federal State Budgetary Scientific Institution 'Petrovsky National Research Centre of Surgery', Moscow, Russia.
Jazyk: angličtina
Zdroj: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections [Dokl Biol Sci] 2023 Aug; Vol. 511 (1), pp. 241-246. Date of Electronic Publication: 2023 Oct 13.
DOI: 10.1134/S0012496623700394
Abstrakt: The aim of the study is to investigate the growth and development of B16 melanoma in mature male C57Black/6 mice with a post-traumatic stress disorder (PTSD) model. Behavioral, immunohistochemical, morphometric methods, enzyme immunoassay were used. A forced decrease in the level of corticosterone, which is characteristic for PTSD, was established, followed by intensification of the production of increased concentrations of pro-inflammatory interleukins by the cells of the immune system and, at the same time, a decrease in the secretion of anti-inflammatory cytokines. Priority data were obtained: the neurohumoral imbalance that develops in PTSD is a limiting factor to the growth of B16 melanoma, at least at the initial stages of the oncological process.
(© 2023. Pleiades Publishing, Ltd.)
Databáze: MEDLINE
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