Insight into the degradation of amino substituted benzimidazo[1,2-a]quinolines via a combined experimental and density functional theory study.

Autor: Tolić Čop K; University of Zagreb, Faculty of Chemical Engineering and Technology, Department of Analytical Chemistry, Marulićev trg 19, 10000 Zagreb, Croatia., Perin N; University of Zagreb, Faculty of Chemical Engineering and Technology, Department of Organic Chemistry, Marulićev trg 19, 10000 Zagreb, Croatia., Hranjec M; University of Zagreb, Faculty of Chemical Engineering and Technology, Department of Organic Chemistry, Marulićev trg 19, 10000 Zagreb, Croatia., Runje M; Pliva Croatia TAPI R&D, Prilaz baruna Filipovića 25, 10000 Zagreb, Croatia., Vianello R; Laboratory for the Computational Design and Synthesis of Functional Materials, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia. Electronic address: robert.vianello@irb.hr., Gazivoda Kraljević T; University of Zagreb, Faculty of Chemical Engineering and Technology, Department of Organic Chemistry, Marulićev trg 19, 10000 Zagreb, Croatia. Electronic address: tgazivod@fkit.hr., Mutavdžić Pavlović D; University of Zagreb, Faculty of Chemical Engineering and Technology, Department of Analytical Chemistry, Marulićev trg 19, 10000 Zagreb, Croatia. Electronic address: dmutavdz@fkit.hr.
Jazyk: angličtina
Zdroj: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2024 Jan 05; Vol. 237, pp. 115767. Date of Electronic Publication: 2023 Oct 06.
DOI: 10.1016/j.jpba.2023.115767
Abstrakt: Heterocyclic compounds have been shown to be potential chemotherapeutic agents, especially the benzimidazole derivatives studied in this work. The ultimate goal in the search for biologically active and effective molecules is to commercialize a product whose stability must be reliable. Therefore, in the development of drugs, forced degradation experiments are performed under the environmental conditions to which they are subjected during transportation and storage to ensure quality and safety before marketing. Hydrolytic, thermal, photolytic, and degradation in the presence of hydrogen peroxide are experimental stress tests to which the newly synthesized compounds were subjected to gain insight into the degradation pathways of the analytes. Degradation of two benzimidazole derivatives was observed under all applied conditions while the major impact showed photolysis with ten and four degradation products, respectively. In total, eighteen major degradation products were detected and identified using high-resolution mass spectrometry. Computer models in the TEST program were applied to the proposed structures to evaluate the bioaccumulation factor, toxicity, and mutagenicity of the analyzed compounds, while density functional theory analysis (DFT) revealed factors affecting the vulnerability of systems towards exceeding acidic/basic conditions and H 2 O 2 .
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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