Renal medullary oxygenation during laparoscopic vs open surgery: the impact of blood pressure management-a pilot randomized controlled trial.

Autor: Chaba A; Department of Intensive Care, Austin Hospital, 145 Studley Road, Heidelberg, Melbourne, VIC, 3084, Australia. anis.chaba@austin.org.au., Hacking D; Department of Anesthesia, Austin Hospital, Melbourne, Australia., Slifirski H; Department of Anesthesia, Austin Hospital, Melbourne, Australia., Cogan R; Department of Anesthesia, Austin Hospital, Melbourne, Australia., Spano S; Department of Intensive Care, Austin Hospital, 145 Studley Road, Heidelberg, Melbourne, VIC, 3084, Australia., Maeda A; Department of Intensive Care, Austin Hospital, 145 Studley Road, Heidelberg, Melbourne, VIC, 3084, Australia., Eastwood G; Department of Intensive Care, Austin Hospital, 145 Studley Road, Heidelberg, Melbourne, VIC, 3084, Australia., Bellomo R; Department of Intensive Care, Austin Hospital, 145 Studley Road, Heidelberg, Melbourne, VIC, 3084, Australia.; Department of Critical Care, The University of Melbourne, Melbourne, Australia.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia.; Data Analytics Research and Evaluation Centre, Austin Hospital, Melbourne, Australia.; Department of Intensive Care, Royal Melbourne Hospital, Melbourne, Australia.
Jazyk: angličtina
Zdroj: Journal of clinical monitoring and computing [J Clin Monit Comput] 2024 Apr; Vol. 38 (2), pp. 337-345. Date of Electronic Publication: 2023 Oct 13.
DOI: 10.1007/s10877-023-01079-1
Abstrakt: The impact of blood pressure targets and surgical approach (laparoscopic or open) on continuous urinary oxygenation (PuO 2 ), a validated surrogate of renal medullary PO 2 , during general surgery, is unclear. We aimed to assess the effects of different blood pressure targets and surgical procedures on PuO 2 . We randomized patients receiving either laparoscopic or open surgery into two mean arterial pressure (MAP) target groups: usual MAP or a high MAP. We measured PuO 2 in real-time and analyzed it according to the type of surgery and blood pressure target. The study was retrospectively registered on the 5th of July 2023 (ACTRN12623000726651). We included 43 participants who underwent either laparoscopic (n = 20) or open surgery (n = 23). We found that PuO 2 significantly decreased during both laparoscopic and open surgery under a usual blood pressure target (- 51% and - 49%, respectively). However, there was a sharper fall with laparoscopic surgery resulting in a higher PuO 2 with open surgery (mean difference: 11 ± 1 mmHg higher; p < 0.001). Targeting a higher MAP resulted in a higher PuO 2 over time during laparoscopic surgery (mean difference: 7 ± 1 mmHg, p < 0.001). In contrast, targeting a usual MAP resulted in a higher PuO 2 during open surgery (mean difference: 7 ± 1 mmHg, p < 0.001). Surgical approach and intraoperative blood pressure targets significantly impact urinary oxygenation. Further studies with larger sample sizes are needed to confirm these findings and understand their potential clinical implications.Registration number: ACTRN12623000726651; Date of registration: 05/07/2023 (retrospectively registered).
(© 2023. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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