Biocompatible, Europium-Doped Fluorapatite Nanoparticles as a Wide-Range pH Sensor.

Autor: Krishnapriya TK; Nanomaterials for Emerging Solid-state Technology (NEST) Research Laboratory, Department of Physics, CUSAT, Kochi, 682022, India., Deepti A; Centre for Neuroscience, Department of Biotechnology, CUSAT, Kochi, 682022, India., Chakrapani PSB; Centre for Neuroscience, Department of Biotechnology, CUSAT, Kochi, 682022, India.; Centre of Excellence in Advanced Materials, CUSAT, Kochi, 682022, India., Asha AS; Nanomaterials for Emerging Solid-state Technology (NEST) Research Laboratory, Department of Physics, CUSAT, Kochi, 682022, India. asa@cusat.ac.in.; Centre of Excellence in Advanced Materials, CUSAT, Kochi, 682022, India. asa@cusat.ac.in.; Inter-University Centre for Nanomaterials and Devices, CUSAT, Kochi, 682022, India. asa@cusat.ac.in., Jayaraj MK; University of Calicut, Malappuram, 673635, India.
Jazyk: angličtina
Zdroj: Journal of fluorescence [J Fluoresc] 2023 Oct 13. Date of Electronic Publication: 2023 Oct 13.
DOI: 10.1007/s10895-023-03461-3
Abstrakt: The development of a simple, biocompatible, pH sensor with a wide range of detection, using a single fluorescent probe is highly important in the medical field for the early detection of diseases related to the pH change of tissues and body fluids. For this purpose, europium-doped fluorapatite (FAP: Eu) nanoparticles were synthesized using the coprecipitation method. Doping with the rare earth element europium (Eu) makes the non-luminescent phosphate mineral fluorapatite, luminescent. The luminous response of the sample upon dissolution in hydrochloric acid (HCl), in highly acidic to weakly basic media, makes it a potential pH sensor. A linear variation was observed with an increase in pH, in both the total intensity of emission and the R-value or the asymmetry ratio. The ratiometric pH sensing enabled by the variation in R-value makes the sensor independent of external factors. The structural, optical, and photoluminescent (PL) lifetime analysis suggests a particle size-dependent pH sensing mechanism with the changes in the coordinated water molecules around the Eu 3+ ion in the nanoparticle. Given its exceptional biocompatibility and pH-dependent fluorescence intensity for a wide range of pH from 0.83 to 8.97, the probe can be used as a potential candidate for pH sensing of biological fluid.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: