Anti-inflammatory activities of flavonoid derivates.

Autor:	Ysrafil Y; Department of Pharmacotherapy, Faculty of Medicine, Universitas Palangka Raya, Palangka Raya 73111, Indonesia., Sapiun Z; Department of Pharmacy, Politeknik Kesehatan Kementerian Kesehatan Gorontalo, Gorontalo 96135, Indonesia., Slamet NS; Department of Pharmacy, Politeknik Kesehatan Kementerian Kesehatan Gorontalo, Gorontalo 96135, Indonesia., Mohamad F; Department of Pharmacy, Politeknik Kesehatan Kementerian Kesehatan Gorontalo, Gorontalo 96135, Indonesia., Hartati H; Department of Pharmacy, Politeknik Kesehatan Kementerian Kesehatan Gorontalo, Gorontalo 96135, Indonesia., Damiti SA; Department of Midwivery, Politeknik Kesehatan Kementerian Kesehatan Palangka Raya 73111, Palangka Raya, Indonesia., Alexandra FD; Department of Pharmacotherapy, Faculty of Medicine, Universitas Palangka Raya, Palangka Raya 73111, Indonesia., Rahman S; Faculty of mathematics and natural sciences, Universitas Palangka Raya, Palangka Raya 73111, Indonesia., Masyeni S; Department of Internal Medicine, Faculty of Medicine and Health Sciences, Universitas Warmadewa, Denpasar, Bali 80235, Indonesia.; Department of Internal Medicine, Sanjiwani Hospital, Denpasar, Bali 80235, Indonesia., Harapan H; Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia.; Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia.; Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia., Mamada SS; Department of Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar 90245, Indonesia., Bin Emran T; Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA.; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh., Nainu F; Department of Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar 90245, Indonesia.
Jazyk:	angličtina
Zdroj:	ADMET & DMPK [ADMET DMPK] 2023 Jul 26; Vol. 11 (3), pp. 331-359. Date of Electronic Publication: 2023 Jul 26 (Print Publication: 2023).
DOI:	10.5599/admet.1918
Abstrakt:	Background and Purpose: Flavonoids are a group of phytochemicals found abundantly in various plants. Scientific evidence has revealed that flavonoids display potential biological activities, including their ability to alleviate inflammation. This activity is closely related to their action in blocking the inflammatory cascade and inhibiting the production of pro-inflammatory factors. However, as flavonoids typically have poor bioavailability and pharmacokinetic profile, it is quite challenging to establish these compounds as a drug. Nevertheless, progressive advancements in drug delivery systems, particularly in nanotechnology, have shown promising approaches to overcome such challenges. Review Approach: This narrative review provides an overview of scientific knowledge about the mechanism of action of flavonoids in the mitigation of inflammatory reaction prior to delivering a comprehensive discussion about the opportunity of the nanotechnology-based delivery system in the preparation of the flavonoid-based drug. Key Results: Various studies conducted in silico, in vitro, in vivo, and clinical trials have deciphered that the anti-inflammatory activities of flavonoids are closely linked to their ability to modulate various biochemical mediators, enzymes, and signalling pathways involved in the inflammatory processes. This compound could be encapsulated in nanotechnology platforms to increase the solubility, bioavailability, and pharmacological activity of flavonoids as well as reduce the toxic effects of these compounds. Conclusion: In Summary, we conclude that flavonoids and their derivates have given promising results in their development as new anti-inflammatory drug candidates, especially if they formulate in nanoparticles. Competing Interests: Conflict of interest: There is no conflict of Interest associated of this article as well as no significant support that influenced the content. (Copyright © 2023 by the authors.)
Databáze:	MEDLINE
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