Unhealthy white matter connectivity, cognition, and racialization in older adults.

Autor: Royse SK; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Snitz BE; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Hengenius JB; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Huppert TJ; Department of Electrical Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Roush RE; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Ehrenkranz RE; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Wilson JD; Department of Mathematics and Statistics, University of San Francisco, San Francisco, California, USA., Bertolet M; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Reese AC; Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Cisneros G; Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Potopenko K; Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Becker JT; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Cohen AD; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Shaaban CE; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Mar; Vol. 20 (3), pp. 1483-1496. Date of Electronic Publication: 2023 Oct 12.
DOI: 10.1002/alz.13494
Abstrakt: Introduction: White matter hyperintensities (WMH) may promote clinical Alzheimer's disease (AD) disparities between Black American (BA) and non-Hispanic White (nHW) populations. Using a novel measurement, unhealthy white matter connectivity (UWMC), we interrogated racialized group differences in associations between WMH in AD pathology-affected regions and cognition.
Methods: UWMC is the proportion of white matter fibers that pass through WMH for every pair of brain regions. Individual regression models tested associations of UWMC in beta-amyloid (Aβ) or tau pathology-affected regions with cognition overall, stratified by racialized group, and with a racialized group interaction.
Results: In 201 older adults ranging from cognitively unimpaired to AD, BA participants exhibited greater UWMC and worse cognition than nHW participants. UWMC was negatively associated with cognition in 17 and 5 Aβ- and tau-affected regions, respectively. Racialization did not modify these relationships.
Discussion: Differential UWMC burden, not differential UWMC-and-cognition associations, may drive clinical AD disparities between racialized groups.
Highlights: Unhealthy white matter connectivity (UWMC) in Alzheimer's disease (AD) pathology-affected brain regions is associated with cognition. Relationships between UWMC and cognition are similar between Black American (BA) and non-Hispanic White (nHW) individuals. More UWMC may partially drive higher clinical AD burden in BA versus nHW populations. UWMC risk factors, particularly social and environmental, should be identified.
(© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze: MEDLINE
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