Key advances in vaccine development for tuberculosis-success and challenges.

Autor: Lai R; Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, MA, USA., Ogunsola AF; Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, MA, USA., Rakib T; Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, MA, USA., Behar SM; Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, MA, USA. samuel.behar@umassmed.edu.
Jazyk: angličtina
Zdroj: NPJ vaccines [NPJ Vaccines] 2023 Oct 13; Vol. 8 (1), pp. 158. Date of Electronic Publication: 2023 Oct 13.
DOI: 10.1038/s41541-023-00750-7
Abstrakt: Breakthrough findings in the clinical and preclinical development of tuberculosis (TB) vaccines have galvanized the field and suggest, for the first time since the development of bacille Calmette-Guérin (BCG), that a novel and protective TB vaccine is on the horizon. Here we highlight the TB vaccines that are in the development pipeline and review the basis for optimism in both the clinical and preclinical space. We describe immune signatures that could act as immunological correlates of protection (CoP) to facilitate the development and comparison of vaccines. Finally, we discuss new animal models that are expected to more faithfully model the pathology and complex immune responses observed in human populations.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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