Flow-mediated dilation as a marker of endothelial dysfunction in pulmonary diseases: A narrative review.

Autor: Abagnale L; Department of Medicine and Surgery, Federico II University, Naples, Italy., Candia C; Department of Medicine and Surgery, Federico II University, Naples, Italy., Motta A; Institute of Biomolecular Chemistry, National Research Council, 80078 Pozzuoli, Naples, Italy., Galloway B; Istituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Unit of Telese Terme Institute, Telese Terme, Italy., Ambrosino P; Istituti Clinici Scientifici Maugeri IRCCS, Directorate of Telese Terme Institute, Telese Terme, Italy., Molino A; Department of Medicine and Surgery, Federico II University, Naples, Italy., Maniscalco M; Department of Medicine and Surgery, Federico II University, Naples, Italy; Istituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Unit of Telese Terme Institute, Telese Terme, Italy. Electronic address: mauro.maniscalco@icsmaugeri.it.
Jazyk: angličtina
Zdroj: Respiratory medicine and research [Respir Med Res] 2023 Nov; Vol. 84, pp. 101049. Date of Electronic Publication: 2023 Sep 16.
DOI: 10.1016/j.resmer.2023.101049
Abstrakt: The endothelium is an active and crucial component of vessels and produces several key regulatory factors for the homeostasis of the entire organism. Endothelial function can be investigated invasively or non-invasively, both in the coronary and peripheral circulation. A widely accepted method for the assessment of endothelial function is measurement of flow-mediated dilation (FMD), which evaluates the vascular response to changes in blood flow. In this current review, we describe FMD applications in the clinical setting of different respiratory diseases: acute SARS-COV2 infection, pulmonary embolism; post-acute SARS-COV2 infection, Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apneas Syndrome, Pulmonary Hypertension, Interstitial Lung Diseases. Emerging evidence shows that FMD might be an effective tool to assess the cardiovascular risk in patients suffering from the undermentioned respiratory diseases as well as an independent predictive factor of disease severity and/or recovery.
Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest to declare.
(Copyright © 2023 SPLF and Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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