Melioidosis Queensland: An analysis of clinical outcomes and genomic factors.

Autor: Gassiep I; The University of Queensland, Faculty of Medicine, UQ Centre for Clinical Research, Herston, Queensland, Australia.; Department of Infectious Diseases, Mater Hospital Brisbane, South Brisbane, Queensland, Australia.; Pathology Queensland, Royal Brisbane & Women's Hospital, Herston, Queensland, Australia., Burnard D; Queensland Cyber Infrastructure Foundation, Brisbane, Queensland, Australia., Permana B; The University of Queensland, Faculty of Medicine, UQ Centre for Clinical Research, Herston, Queensland, Australia.; Herston Infectious Diseases Institute, Metro North Health, Queensland, Australia., Bauer MJ; The University of Queensland, Faculty of Medicine, UQ Centre for Clinical Research, Herston, Queensland, Australia., Cuddihy T; The University of Queensland, Faculty of Medicine, UQ Centre for Clinical Research, Herston, Queensland, Australia., Forde BM; The University of Queensland, Faculty of Medicine, UQ Centre for Clinical Research, Herston, Queensland, Australia., Chatfield MD; The University of Queensland, Faculty of Medicine, UQ Centre for Clinical Research, Herston, Queensland, Australia., Ling W; The University of Queensland, Faculty of Medicine, UQ Centre for Clinical Research, Herston, Queensland, Australia., Norton R; Pathology Queensland, Townsville University Hospital, Townsville, Queensland, Australia.; Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Harris PNA; The University of Queensland, Faculty of Medicine, UQ Centre for Clinical Research, Herston, Queensland, Australia.; Pathology Queensland, Royal Brisbane & Women's Hospital, Herston, Queensland, Australia.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2023 Oct 12; Vol. 17 (10), pp. e0011697. Date of Electronic Publication: 2023 Oct 12 (Print Publication: 2023).
DOI: 10.1371/journal.pntd.0011697
Abstrakt: Background: The clinical and genomic epidemiology of melioidosis varies across regions.
Aim: To describe the clinical and genetic diversity of B. pseudomallei across Queensland, Australia.
Methods: Whole genome sequencing of clinical isolates stored at the melioidosis reference lab from 1996-2020 was performed and analysed in conjunction with available clinical data.
Results: Isolates from 292 patients were analysed. Bacteraemia was present in 71% and pneumonia in 65%. The case-fatality rate was 25%. Novel sequence types (ST) accounted for 51% of all isolates. No association was identified between the variable virulence factors assessed and patient outcome. Over time, the proportion of First Nation's patients declined from 59% to 26%, and the proportion of patients aged >70 years rose from 13% to 38%.
Conclusion: This study describes a genomically diverse and comparatively distinct collection of B. pseudomallei clinical isolates from across Queensland, Australia. An increasing incidence of melioidosis in elderly patients may be an important factor in the persistently high case-fatality in this region and warrants further investigation and directed intervention.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Gassiep et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje