Neuromodulation of striatal D1 cells shapes BOLD fluctuations in anatomically connected thalamic and cortical regions.

Autor:	Markicevic M; Neural Control of Movement Lab, HEST, ETH Zürich, Zurich, Switzerland.; Neuroscience Center Zurich, University and ETH Zurich, Zurich, Switzerland.; Department of Radiology and Biomedical Imaging, School of Medicine, Yale University, New Haven, United States., Sturman O; Neuroscience Center Zurich, University and ETH Zurich, Zurich, Switzerland.; Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, HEST, ETH Zurich, Zurich, Switzerland., Bohacek J; Neuroscience Center Zurich, University and ETH Zurich, Zurich, Switzerland.; Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, HEST, ETH Zurich, Zurich, Switzerland., Rudin M; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland., Zerbi V; Neuro-X Institute, School of Engineering (STI), EPFL, Lausanne, Switzerland.; CIBM Centre for Biomedical Imaging, Lausanne, Switzerland., Fulcher BD; School of Physics, The University of Sydney, Camperdown, Australia., Wenderoth N; Neural Control of Movement Lab, HEST, ETH Zürich, Zurich, Switzerland.; Neuroscience Center Zurich, University and ETH Zurich, Zurich, Switzerland.; Future Health Technologies, Singapore-ETH Centre, Campus for Research Excellence and Technological Enterprise (CREATE), Singapore, Singapore.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2023 Oct 12; Vol. 12. Date of Electronic Publication: 2023 Oct 12.
DOI:	10.7554/eLife.78620
Abstrakt:	Understanding how the brain's macroscale dynamics are shaped by underlying microscale mechanisms is a key problem in neuroscience. In animal models, we can now investigate this relationship in unprecedented detail by directly manipulating cellular-level properties while measuring the whole-brain response using resting-state fMRI. Here, we focused on understanding how blood-oxygen-level-dependent (BOLD) dynamics, measured within a structurally well-defined striato-thalamo-cortical circuit in mice, are shaped by chemogenetically exciting or inhibiting D1 medium spiny neurons (MSNs) of the right dorsomedial caudate putamen (CPdm). We characterize changes in both the BOLD dynamics of individual cortical and subcortical brain areas, and patterns of inter-regional coupling (functional connectivity) between pairs of areas. Using a classification approach based on a large and diverse set of time-series properties, we found that CPdm neuromodulation alters BOLD dynamics within thalamic subregions that project back to dorsomedial striatum. In the cortex, changes in local dynamics were strongest in unimodal regions (which process information from a single sensory modality) and weakened along a hierarchical gradient towards transmodal regions. In contrast, a decrease in functional connectivity was observed only for cortico-striatal connections after D1 excitation. Our results show that targeted cellular-level manipulations affect local BOLD dynamics at the macroscale, such as by making BOLD dynamics more predictable over time by increasing its self-correlation structure. This contributes to ongoing attempts to understand the influence of structure-function relationships in shaping inter-regional communication at subcortical and cortical levels. Competing Interests: MM, OS, JB, MR, VZ, BF, NW No competing interests declared (© 2023, Markicevic et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu