Types of diabetes during pregnancy and risk of depression and anxiety in offspring from childhood to young adulthood.

Autor: Xiang AH; Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA., Lin JC; Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA., Chow T; Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA., Martinez MP; Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA., Negriff S; Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA., Page KA; Division of Endocrinology, Diabetes and Obesity Research Institute, Los Angeles, California, USA., McConnell R; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Carter SA; Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA.
Jazyk: angličtina
Zdroj: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2024 Jan; Vol. 26 (1), pp. 224-232. Date of Electronic Publication: 2023 Oct 12.
DOI: 10.1111/dom.15308
Abstrakt: Aims: To assess maternal pre-existing type 1 diabetes (T1D), type 2 diabetes (T2D), gestational diabetes mellitus (GDM) during pregnancy and risk of depression and anxiety from childhood to young adulthood in offspring.
Materials and Methods: This birth cohort included singletons born during 1995-2015, followed using electronic medical records through 2020. Cox regression was used to estimate hazard ratio (HR) of depression or anxiety diagnosis during follow-up associated with in-utero exposure to maternal diabetes.
Results: Among 439 590 offspring, 29 891 (6.8%) had depression and 51 918 (11.8%) had anxiety. T1D, followed by T2D and GDM requiring antidiabetes medication were associated with risk of depression and anxiety in offspring. Compared with no diabetes during pregnancy, the adjusted HRs (95% confidence interval) of depression in offspring associated with T1D, T2D or GDM requiring medications were 1.44 (1.09-1.91), 1.30 (1.15-1.47) and 1.18 (1.11-1.26) respectively; conversely, HRs were 0.97 (0.82-1.15) for T2D and 0.99 (0.94-1.04) for GDM without medications. The associations with anxiety followed similar patterns. The significant associations were observed for offspring ages 5-12 and >12-18 years and attenuated for 18-25 years.
Conclusion: These data suggest that the severity of diabetes (T1D vs. T2D requiring medications vs. GDM requiring medications) during pregnancy may increase the vulnerability of offspring for depression or anxiety.
(© 2023 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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