SWATH-MS analysis of plasma proteins among Indian HIV-1 infected patients.
| Autor: | Barik SK; ICMR-National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Agra, Uttar-Pradesh, India-282004., Tripathy SP; ICMR-National Institute for Research in Tuberculosis, Chetpet, Chennai, Tamil Nadu, India-600031., Bisht D; ICMR-National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Agra, Uttar-Pradesh, India-282004., Singh P; CSIR-Institute of Genomics and Integrative Biology, CSIR, New Delhi-110025., Chakraborty R; CSIR-Institute of Genomics and Integrative Biology, CSIR, New Delhi-110025., Patil SA; ICMR-National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Agra, Uttar-Pradesh, India-282004., Singh TP; Sarojini Naidu Medical College, Agra, Uttar-Pradesh, India-282003., Varshney D; ICMR-National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Agra, Uttar-Pradesh, India-282004., Jena S; Ravenshaw University, Odisha, Cuttack, India - 753003., Mohanty KK; ICMR-National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Agra, Uttar-Pradesh, India-282004. |
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| Jazyk: | angličtina |
| Zdroj: | Bioinformation [Bioinformation] 2023 Apr 30; Vol. 19 (4), pp. 392-398. Date of Electronic Publication: 2023 Apr 30 (Print Publication: 2023). |
| DOI: | 10.6026/97320630019392 |
| Abstrakt: | The identification and characterization of plasma proteins in drug resistant and drug sensitive in HIV-1 infected/AIDS patients were carried out using the SWATH-MS protocol. In total, 204 proteins were identified and quantified, 57 proteins were differentially expressed, out of which 25 proteins were down regulated and 32 proteins were up regulated in drug resistant patients. Six proteins such as complement C4-A, immunoglobulin heavy variable 1-2, carboxylic ester hydrolase, fibulin-1, immunoglobulin lambda constant7, secreted phosphoprotein 24 were differentially expressed in individuals with drug resistant HIV as compared to individuals with drug sensitive HIV. Gene ontology of 57 differentially expressed proteins was analysed and documented. Competing Interests: All authors declare no conflict of interest. (© 2023 Biomedical Informatics.) |
| Databáze: | MEDLINE |
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