Desnutrin as a Biomarker for Insulin Resistance in Patients with Vitiligo Vulgaris.

Autor: El-Hamd MA; From the Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt., Sedky A; Department of Clinical Pathology, Faculty of Medicine, Sohag University, Sohag, Egypt., Mahmoud AB; From the Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt., Abd El-Magid WM; From the Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt.
Jazyk: angličtina
Zdroj: Indian journal of dermatology [Indian J Dermatol] 2023 Jul-Aug; Vol. 68 (4), pp. 366-371.
DOI: 10.4103/ijd.ijd_435_22
Abstrakt: Background: Vitiligo is a common depigmented skin disorder characterised by the selective destruction of melanocytes.
Aims and Objectives: This study aimed to assess serum desnutrin and its association with insulin resistance in patients with vitiligo vulgaris.
Materials and Methods: This study was a cross-sectional case-control study. It included 45 patients with vitiligo vulgaris and 45 age- and sex-matched healthy controls. Patients were subjected to complete general and cutaneous evaluations. All participants were subjected to the assay of fasting blood glucose (FBG), cholesterol, triglyceride, high-density lipoprotein (HDL), very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), fasting serum insulin and serum desnutrin. Homeostasis Model Assessment + insulin resistance (HOMA + IR) was calculated for all participants.
Results: There were statistically significant differences between the patients with vitiligo vulgaris and healthy controls regarding HDL, FBG, fasting insulin, HOMA-IR, and serum desnutrin ( P < 0.001). Desnutrin levels were negatively correlated with FBS, LDL, VLDL, fasting insulin, and HOMA-IR ( P < 0.05). Unlikely, the level of desnutrin had a positive, non-significant correlation with HDL (rho = 0.17, P = 0.059).
Conclusion: This study concluded that in patients with vitiligo vulgaris, as a result of increased serum levels of glucose and insulin, the serum desnutrin was suppressed, perhaps contributing to hyperlipidaemia and IR. So, low serum desnutrin could be a biomarker for IR in patients with vitiligo vulgaris. A multidisciplinary approach is essential for the early detection of diabetes mellitus, IR and hyperlipidemia among patients with vitiligo vulgaris to avoid cardiovascular and metabolic complications.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2023 Indian Journal of Dermatology.)
Databáze: MEDLINE
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