Immunosenescence and inflammatory markers in Cuban centenarians: implications for survival.

Autor: Ledón N; Research Direction, Center of Molecular Immunology, Havana, Cuba.; School of Pharmacy, University of Havana, Havana, Cuba., Añé-Kourí AL; Clinical Research Direction, Center of Molecular Immunology, Havana, Cuba.; Department of Biochemistry, Instituto de Ciencias Básicas y Preclínicas 'Victoria de Girón', Havana, Cuba., Ramos MB; Geriatric Department, University Hospital General Calixto García, Havana, Cuba., Lorenzo-Luaces P; Clinical Research Direction, Center of Molecular Immunology, Havana, Cuba., Silva A; Research Direction, Center of Molecular Immunology, Havana, Cuba., Pereira K; Research Direction, Center of Molecular Immunology, Havana, Cuba., Lage A; Clinical Research Direction, Center of Molecular Immunology, Havana, Cuba., Saavedra D; Clinical Research Direction, Center of Molecular Immunology, Havana, Cuba. danays@cim.sld.cu.; Department of Immunology, Instituto de Ciencias Básicas y Preclínicas 'Victoria de Girón', Havana, Cuba. danays@cim.sld.cu.
Jazyk: angličtina
Zdroj: Aging clinical and experimental research [Aging Clin Exp Res] 2023 Nov; Vol. 35 (11), pp. 2839-2842. Date of Electronic Publication: 2023 Oct 12.
DOI: 10.1007/s40520-023-02567-9
Abstrakt: Centenarians are the best example of successful aging in humans. This work aimed to understand if immune status is associated with survival in Cuban centenarians. In a previous study, our group enrolled 43 centenarians and evaluated their immune status and functional capacity. 41 out of 43 recruited centenarians received follow-up phone calls, during a period of 2 years. Absolute CD4 + T cell count was higher among survivors, while the frequency of CD8 + CCR7-CD45RA + , CD8 + CD45RA + CD28-, and CD4 + CD28- T cells was higher among non-survivors. We also found that higher frequencies of terminally differentiated T cells were related to a higher risk of death, while centenarians with higher frequencies of T cells were more likely to survive. Surprisingly, neither serum inflammatory markers nor frailty/dependency was associated with survival. Our preliminary study suggests that immuno-senescence markers, but not inflammaging or functional capacity, are associated with survival beyond 100 years in a small group of Cuban centenarians.
(© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Databáze: MEDLINE
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