Comparison of the management of Helicobacter pylori infection between the older and younger European populations.

Autor: Jonaitis P; Department of Gastroenterology, Lithuanian University of Health Sciences, 50161, Kaunas, Lithuania., Nyssen OP; Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad Autónoma de Madrid (UAM), Diego de León, 62, 28006, Madrid, Spain. opn.aegredcap@aegastro.es., Saracino IM; Department of Surgical and Medical Sciences, IRCCS AOUBO, University of Bologna, 40138, Bologna, Italy., Fiorini G; Department of Surgical and Medical Sciences, IRCCS AOUBO, University of Bologna, 40138, Bologna, Italy., Vaira D; Department of Surgical and Medical Sciences, IRCCS AOUBO, University of Bologna, 40138, Bologna, Italy., Pérez-Aísa Á; Agencia Sanitaria Costa del Sol, Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), 29651, Marbella, Spain., Tepes B; Department of Gastroenterology, AM DC Rogaska, 3250, Rogaska Slatina, Slovenia., Castro-Fernandez M; Department of Gastroenterology, Hospital de Valme, 41014, Seville, Spain., Pabón-Carrasco M; Department of Gastroenterology, Hospital de Valme, 41014, Seville, Spain., Keco-Huerga A; Department of Gastroenterology, Hospital de Valme, 41014, Seville, Spain., Voynovan I; Department of Gastroenterology, A.S. Loginov Moscow Clinical Scientific Center, 111123, Moscow, Russia., Lucendo AJ; Department of Gastroenterology, Hospital General de Tomelloso, 13700, Tomelloso, Spain., Lanas Á; IIS Aragón y Facultad de Medicina de la Universidad de Zaragoza, 50009, Zaragoza, Spain., Martínez-Domínguez SJ; IIS Aragón y Facultad de Medicina de la Universidad de Zaragoza, 50009, Zaragoza, Spain., Almajano EA; IIS Aragón y Facultad de Medicina de la Universidad de Zaragoza, 50009, Zaragoza, Spain., Rodrigo L; Gastroenterology Unit, Hospital Universitario Central de Asturias, 33011, Oviedo, Spain., Vologzanina L; Department of Gastroenterology, Gastrocentre, 614068, Perm, Russia., Brglez Jurecic N; Department of Gastroenterology, Interni Oddelek, Diagnostic Centre, 4260, Bled, Slovenia., Denkovski M; Department of Gastroenterology, Interni Oddelek, Diagnostic Centre, 4260, Bled, Slovenia., Bujanda L; Hospital Donostia, Instituto Biodonostia, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad del País Vasco (UPV/EHU), 20018, San Sebastián, Spain., Mahmudov U; Modern Hospital, 1119, Baku, Azerbaijan., Leja M; Department of Gastroenterology, Digestive Diseases Centre Gastro, Institute of Clinical and Preventive Medicine and Faculty of Medicine, University of Latvia, Riga, 1079, Latvia., Lerang F; Department of Gastroenterology, Østfold Hospital Trust, 1714, Grålum, Norway., Babayeva G; Memorial Klinik, 1096, Baku, Azerbaijan., Bordin DS; Department of Gastroenterology, A.S. Loginov Moscow Clinical Scientific Center, 111123, Moscow, Russia.; A.I. Yevdokimov Moscow State University of Medicine and Dentistry, 127473, Moscow, Russia.; Tver State Medical University, 170100, Tver, Russia., Gasbarrini A; Medicina Interna, Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Università Cattolica del Sacro Cuore, 00168, Rome, Italy., Kupcinskas J; Department of Gastroenterology, Lithuanian University of Health Sciences, 50161, Kaunas, Lithuania., Gridnyev O; Government Institution 'L.T.Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine', Kyiv, Ukraine., Rokkas T; Department of Gastroenterology, Henry Dunant Hospital, 115 26, Athens, Greece., Marcos-Pinto R; Department of Gastroenterology, Centro Hospitalar do Porto Institute of Biomedical Sciences Abel Salazar, Centro de Investigação em Tecnologias e Serviços de Saúde, University of Porto, 4050-313, Porto, Portugal., Phull PS; Department of Gastroenterology, Aberdeen Royal Infirmary, Aberdeen, AB25 2ZN, UK., Smith SM; Faculty of Health Sciences, Trinity College Dublin, Dublin, D02PN40, Ireland., Tonkić A; Department of Gastroenterology, University Hospital of Split, University of Split School of Medicine, 21000, Split, Croatia., Boltin D; Division of Gastroenterology, Rabin Medical Center, Sackler School of Medicine, Tel Aviv University, 49100, Tel Aviv, Israel., Buzás GM; Department of Gastroenterology, Ferencváros Health Centre, 1095, Budapest, Hungary., Šembera Š; 2nd Department of Internal Medicine and Gastroenterology, University Hospital and Charles University, Faculty of Medicine in Hradec Králové, 500 03, Hradec Králové, Czech Republic., Şimşek H; Division of Gastroenterology and Hepatology, Hacettepe University School of Medicine, 06230, Ankara, Turkey., Matysiak-Budnik T; Department of Gastroenterology, CHRU de Nantes, Hôpital Hôtel Dieu, 44000, Nantes, France., Milivojevic V; Department of Gastroenterology, Clinical Center of Serbia, University of Belgrade School of Medicine, 11000, Belgrade, Serbia., Marlicz W; Department of Gastroenterology, Pomeranian Medical University, 70-204, Szczecin, Poland., Venerito M; Department of Gastroenterology, Otto-Von-Guericke University, 39120, Magdeburg, Germany., Boyanova L; Department of Gastroenterology, Medical Microbiology, Medical University of Sofia, 1431, Sofia, Bulgaria., Doulberis M; Division of Gastroenterology and Hepatology, Medical University Department, Kantonsspital Aarau, 5001, Aarau, Switzerland., Capelle LG; Department of Gastroenterology, Meander Medical Center, 3813 TZ, Amersfoort, The Netherlands., Cano-Català A; GOES Research Group, Althaia Xarxa Assistencial Universitària de Manresa, 08243, Manresa, Spain., Moreira L; Department of Gastroenterology, Hospital Clínic Barcelona, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), University of Barcelona, 08036, Barcelona, Spain., Mégraud F; INSERM U1312, Université de Bordeaux, 33000, Bordeaux, France., O'Morain C; Faculty of Health Sciences, Trinity College Dublin, Dublin, D02PN40, Ireland., Gisbert JP; Gastroenterology Unit, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad Autónoma de Madrid (UAM), Diego de León, 62, 28006, Madrid, Spain., Jonaitis L; Department of Gastroenterology, Lithuanian University of Health Sciences, 50161, Kaunas, Lithuania.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Oct 11; Vol. 13 (1), pp. 17235. Date of Electronic Publication: 2023 Oct 11.
DOI: 10.1038/s41598-023-43287-4
Abstrakt: The prevalence of Helicobacter pylori remains high in the older population. Specific age-related peculiarities may impact the outcomes of H. pylori treatment. The aim of the study was to evaluate the diagnostics and effectiveness of H. pylori eradication between the younger and older European populations. "European Registry on H. pylori Management (Hp-EuReg)" data from 2013 to 2022 were analyzed. Patients were divided into older (≥ 60 years) and younger (18-59 years) groups. Modified intention-to-treat (mITT) and per-protocol (PP) analysis was performed. 49,461 patients included of which 14,467 (29%) were older-aged. Concomitant medications and penicillin allergy were more frequent among the older patients. Differences between younger and older populations were observed in treatment duration in first-line treatment and in proton pump inhibitors (PPIs) doses in second-line treatment. The overall incidence of adverse events was lower in the older adults group. The overall first-line treatment mITT effectiveness was 88% in younger and 90% in the older patients (p < 0.05). The overall second-line mITT treatment effectiveness was 84% in both groups. The effectiveness of the most frequent first- and second-line triple therapies was suboptimal (< 90%) in both groups. Optimal efficacy (≥ 90%) was achieved by using bismuth and non-bismuth-based quadruple therapies. In conclusion, the approach to the diagnostics and treatment of H. pylori infection did not generally differ between younger and older patients. Main differences were reported in the concurrent medications, allergy to penicillin and adverse events both in first- and second-line treatment. Optimal effectiveness rates were mostly achieved by using bismuth and non-bismuth-based quadruple therapies. No clinically relevant differences in the effectiveness between the age groups were observed.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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