Diminished baseline autonomic outflow in semantic dementia relates to left-lateralized insula atrophy.

Autor:	Hua AY; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, CA, USA., Roy ARK; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, CA, USA., Kosik EL; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, CA, USA., Morris NA; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, CA, USA., Chow TE; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, CA, USA., Lukic S; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, CA, USA., Montembeault M; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, CA, USA., Borghesani V; Department of Psychology, University of Geneva, Geneva, Switzerland., Younes K; Department of Neurology, Stanford Neuroscience Health Center, Palo Alto, CA, USA., Kramer JH; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, CA, USA., Seeley WW; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, CA, USA., Perry DC; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, CA, USA., Miller ZA; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, CA, USA., Rosen HJ; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, CA, USA., Miller BL; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, CA, USA., Rankin KP; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, CA, USA., Gorno-Tempini ML; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, CA, USA., Sturm VE; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, CA, USA. Electronic address: Virginia.Sturm@ucsf.edu.
Jazyk:	angličtina
Zdroj:	NeuroImage. Clinical [Neuroimage Clin] 2023; Vol. 40, pp. 103522. Date of Electronic Publication: 2023 Oct 02.
DOI:	10.1016/j.nicl.2023.103522
Abstrakt:	In semantic dementia (SD), asymmetric degeneration of the anterior temporal lobes is associated with loss of semantic knowledge and alterations in socioemotional behavior. There are two clinical variants of SD: semantic variant primary progressive aphasia (svPPA), which is characterized by predominant atrophy in the anterior temporal lobe and insula in the left hemisphere, and semantic behavioral variant frontotemporal dementia (sbvFTD), which is characterized by predominant atrophy in those structures in the right hemisphere. Previous studies of behavioral variant frontotemporal dementia, an associated clinical syndrome that targets the frontal lobes and anterior insula, have found impairments in baseline autonomic nervous system activity that correlate with left-lateralized frontotemporal atrophy patterns and disruptions in socioemotional functioning. Here, we evaluated whether there are similar impairments in resting autonomic nervous system activity in SD that also reflect left-lateralized atrophy and relate to diminished affiliative behavior. A total of 82 participants including 33 people with SD (20 svPPA and 13 sbvFTD) and 49 healthy older controls completed a laboratory-based assessment of respiratory sinus arrhythmia (RSA; a parasympathetic measure) and skin conductance level (SCL; a sympathetic measure) during a two-minute resting baseline period. Participants also underwent structural magnetic resonance imaging, and informants rated their current affiliative behavior on the Interpersonal Adjective Scale. Results indicated that baseline RSA and SCL were lower in SD than in healthy controls, with significant impairments present in both svPPA and sbvFTD. Voxel-based morphometry analyses revealed left-greater-than-right atrophy related to diminished parasympathetic and sympathetic outflow in SD. While left-lateralized atrophy in the mid-to-posterior insula correlated with lower RSA, left-lateralized atrophy in the ventral anterior insula correlated with lower SCL. In SD, lower baseline RSA, but not lower SCL, was associated with lower gregariousness/extraversion. Neither autonomic measure related to warmth/agreeableness, however. Through the assessment of baseline autonomic nervous system physiology, the present study contributes to expanding conceptualizations of the biological basis of socioemotional alterations in svPPA and sbvFTD. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Published by Elsevier Inc.)
Databáze:	MEDLINE
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