Medications for Opioid Use Disorder and Mortality and Hospitalization Among People With Opioid Use-related Infections.

Autor:	Figgatt MC; From the Department of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, NC.; University of North Carolina Injury Prevention Research Center, Chapel Hill, NC., Hincapie-Castillo JM; From the Department of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, NC.; University of North Carolina Injury Prevention Research Center, Chapel Hill, NC., Schranz AJ; Division of Infectious Diseases, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC., Dasgupta N; University of North Carolina Injury Prevention Research Center, Chapel Hill, NC.; University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, NC., Edwards JK; From the Department of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, NC., Jackson BE; Cancer Information and Population Health Resource, University of North Carolina Lineberger Cancer Center, Chapel Hill, NC., Marshall SW; From the Department of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, NC.; University of North Carolina Injury Prevention Research Center, Chapel Hill, NC., Golightly YM; From the Department of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, NC.; University of Nebraska Medical Center College of Allied Health Professions, Omaha, NE.
Jazyk:	angličtina
Zdroj:	Epidemiology (Cambridge, Mass.) [Epidemiology] 2024 Jan 01; Vol. 35 (1), pp. 7-15. Date of Electronic Publication: 2023 Oct 11.
DOI:	10.1097/EDE.0000000000001681
Abstrakt:	Background: Severe skin and soft tissue infections related to injection drug use have increased in concordance with a shift to heroin and illicitly manufactured fentanyl. Opioid agonist therapy medications (methadone and buprenorphine) may improve long-term outcomes by reducing injection drug use. We aimed to examine the association of medication use with mortality among people with opioid use-related skin or soft tissue infections. Methods: An observational cohort study of Medicaid enrollees aged 18 years or older following their first documented medical encounters for opioid use-related skin or soft tissue infections during 2007-2018 in North Carolina. The exposure was documented medication use (methadone or buprenorphine claim) in the first 30 days following initial infection compared with no medication claim. Using Kaplan-Meier estimators, we examined the difference in 3-year incidence of mortality by medication use, weighted for year, age, comorbidities, and length of hospital stay. Results: In this sample, there were 13,286 people with opioid use-related skin or soft tissue infections. The median age was 37 years, 68% were women, and 78% were white. In Kaplan-Meier curves for the total study population, 12 of every 100 patients died during the first 3 years. In weighted models, for every 100 people who used medications, there were four fewer deaths over 3 years (95% confidence interval = 2, 6). Conclusion: In this study, people with opioid use-related skin and soft tissue infections had a high risk of mortality following their initial healthcare visit for infections. Methadone or buprenorphine use was associated with reductions in mortality. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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