Microdosimetric analysis of the radiation quality of two different proton beams in the distal edge of the depth-dose profile.

Autor:	Bianchi A; INFN-Laboratori Nazionali di Legnaro, 35020 Legnaro, Italy., Selva A; INFN-Laboratori Nazionali di Legnaro, 35020 Legnaro, Italy., Rossignoli M; INFN-Laboratori Nazionali di Legnaro, 35020 Legnaro, Italy., Pasquato F; INFN-Laboratori Nazionali di Legnaro, 35020 Legnaro, Italy., Missiaggia M; University of Trento, Dipartimento di Fisica, 38123 Povo Trento, Italy.; Trento Institute of Fundamental Physics and Applications, 38123 Povo Trento, Italy., La Tessa C; University of Trento, Dipartimento di Fisica, 38123 Povo Trento, Italy.; Trento Institute of Fundamental Physics and Applications, 38123 Povo Trento, Italy., Scifoni E; Trento Institute of Fundamental Physics and Applications, 38123 Povo Trento, Italy., Tommasino F; University of Trento, Dipartimento di Fisica, 38123 Povo Trento, Italy.; Trento Institute of Fundamental Physics and Applications, 38123 Povo Trento, Italy., Conte V; INFN-Laboratori Nazionali di Legnaro, 35020 Legnaro, Italy.
Jazyk:	angličtina
Zdroj:	Radiation protection dosimetry [Radiat Prot Dosimetry] 2023 Oct 11; Vol. 199 (15-16), pp. 1979-1983.
DOI:	10.1093/rpd/ncac236
Abstrakt:	Proton-therapy exploits the advantageous depth-dose profile of protons to induce the highest damage to tumoral cells in the last millimetres of their range in sharp Bragg Peak. To cover the whole tumoral volume, beams of different energies are combined to create the Spread Out Bragg Peak (SOBP). In passive modulated beams, the energy spread is created with modulators in which the highest energy beam is degraded through different thicknesses of calibrated plastic materials. The highest energy is chosen depending on the deepest point that needs to be treated. This study aims to investigate differences in the radiation quality in the distal edge of SOBP beams with different initial energy and modulation techniques based on microdosimetric measurements with mini Tissue-Equivalent Proportional Counters. The beams investigated are the 62 MeV proton SOBP of the clinical facility of CATANA and the 148 MeV proton SOBP of the research beam line of the proton-therapy centre of Trento. (© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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