Case report: Cardiac intimal sarcoma in a young child.

Autor:	Verbeek S; Department of Pathology, University Hospitals Leuven, Leuven, Belgium., Sciot R; Department of Pathology, University Hospitals Leuven, Leuven, Belgium., Debiec-Rychter M; Center for Human Genetics, Catholic University Leuven, Leuven, Belgium., Labarque V; Department of Pediatric Hematology and Oncology, University Hospitals Leuven, Leuven, Belgium., Meyns B; Department of Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium., Cools B; Department of Pediatric and Congenital Cardiology, University Hospitals Leuven, Leuven, Belgium.
Jazyk:	angličtina
Zdroj:	Frontiers in pediatrics [Front Pediatr] 2023 Sep 25; Vol. 11, pp. 1238847. Date of Electronic Publication: 2023 Sep 25 (Print Publication: 2023).
DOI:	10.3389/fped.2023.1238847
Abstrakt:	Undifferentiated mesenchymal tumors from the intimal layer (intimal sarcomas) are rare within the ventricles and exceptional in children. A rare case of an intimal sarcoma located in the right ventricle in a young child is presented with need for urgent surgical resection due to mechanical flow obstruction. Tumor cells showed amplification of MDM2 gene and a homozygous loss of CDKN2A on 9p21. A review of the literature regarding primary cardiac malignancies and intimal sarcoma in children is provided. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2023 Verbeek, Sciot, Debiec-Rychter, Labarque, Meyns and Cools.)
Databáze:	MEDLINE
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