Cross-Talk Between Selenium Nanoparticles and Cancer Treatment Through Autophagy.

Autor: Ali W; College of Veterinary Medicine, Yangzhou University Yangzhou, Yangzhou, Jiangsu, 225009, People's Republic of China.; Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, 225009, People's Republic of China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, 225009, People's Republic of China., Chen Y; College of Veterinary Medicine, Yangzhou University Yangzhou, Yangzhou, Jiangsu, 225009, People's Republic of China.; Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, 225009, People's Republic of China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, 225009, People's Republic of China., Gandahi JA; College of Veterinary Medicine, Yangzhou University Yangzhou, Yangzhou, Jiangsu, 225009, People's Republic of China.; Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, 225009, People's Republic of China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, 225009, People's Republic of China., Qazi IH; College of Veterinary Medicine, Yangzhou University Yangzhou, Yangzhou, Jiangsu, 225009, People's Republic of China.; Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, 225009, People's Republic of China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, 225009, People's Republic of China., Sun J; College of Veterinary Medicine, Yangzhou University Yangzhou, Yangzhou, Jiangsu, 225009, People's Republic of China.; Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, 225009, People's Republic of China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, 225009, People's Republic of China., Wang T; College of Veterinary Medicine, Yangzhou University Yangzhou, Yangzhou, Jiangsu, 225009, People's Republic of China.; Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, 225009, People's Republic of China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, 225009, People's Republic of China., Liu Z; College of Veterinary Medicine, Yangzhou University Yangzhou, Yangzhou, Jiangsu, 225009, People's Republic of China. liuzongping@yzu.edu.cn.; Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, 225009, People's Republic of China. liuzongping@yzu.edu.cn.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, 225009, People's Republic of China. liuzongping@yzu.edu.cn., Zou H; College of Veterinary Medicine, Yangzhou University Yangzhou, Yangzhou, Jiangsu, 225009, People's Republic of China. zouhui@yzu.edu.cn.; Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, 225009, People's Republic of China. zouhui@yzu.edu.cn.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, 225009, People's Republic of China. zouhui@yzu.edu.cn.
Jazyk: angličtina
Zdroj: Biological trace element research [Biol Trace Elem Res] 2024 Jul; Vol. 202 (7), pp. 2931-2940. Date of Electronic Publication: 2023 Oct 10.
DOI: 10.1007/s12011-023-03886-8
Abstrakt: Autophagy is commonly referred as self-eating and a complex cellular process that is involved in the digestion of protein and damaged organelles through a lysosome-dependent mechanism, and this mechanism is essential for maintaining proper cellular homeostasis. Selenium is a vital trace element that plays essential functions in antioxidant defense, redox state control, and range of particular metabolic processes. Selenium nanoparticles have become known as a promising agent for biomedical use, because of their high bioavailability, low toxicity, and degradability. However, and in recent years, they have attracted the interest of researchers in developing anticancer nano-drugs. Selenium nanoparticles can be used as a potential therapeutic agent or in combination with other agents to act as carriers for the development of new treatments. More intriguingly, selenium nanoparticles have been extensively shown to impact autophagy signaling, allowing selenium nanoparticles to be used as possible cancer treatment agents. This review explored the connections between selenium and autophagy, followed by developments and current advances of selenium nanoparticles for autophagy control in various clinical circumstances. Furthermore, this study examined the functions and possible processes of selenium nanoparticles in autophagy regulation, which may help us understand how selenium nanoparticles regulate autophagy for the potential cancer treatment.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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