Green synthesis of nano-based drug delivery systems developed for hepatocellular carcinoma treatment: a review.

Autor: Khafaga DSR; Department of Basic Medical Sciences, Faculty of Medicine, Galala University, Suez, 43511, Egypt. doaa.rashwan@gu.edu.eg., El-Khawaga AM; Department of Basic Medical Sciences, Faculty of Medicine, Galala University, Suez, 43511, Egypt. Ahmed.Elkhawaga@gu.edu.eg., Elfattah Mohammed RA; Faculty of medicine for girls, Internal medicine Al Azher university, Cairo, Egypt., Abdelhakim HK; Biochemistry Division, Faculty of Science, Cairo University, Giza, 12613, Egypt.
Jazyk: angličtina
Zdroj: Molecular biology reports [Mol Biol Rep] 2023 Dec; Vol. 50 (12), pp. 10351-10364. Date of Electronic Publication: 2023 Oct 10.
DOI: 10.1007/s11033-023-08823-5
Abstrakt: This review presents an overview of one of the effective strategies for improving the anticancer impact of many drugs including sorafenib using a drug delivery system by employing nanoparticles that is produced through a biological system. The biological process has a lot of benefits, including being inexpensive and safe for the environment. Sorafenib is one of a multi-kinase inhibitor that inhibits molecularly targeted kinases. Because of its poor pharmacokinetic characteristics, such as fast elimination and limited water solubility, the bioavailability of Sorafenib is extremely low. More intelligent nano formulations of sorafenib have been developed to boost both the drug's target ability and bioavailability. Researchers in a wide variety of sectors, including nanomedicine, have recently been interested in the topic of nanotechnology. It is possible for the body to develop resistance to widely used drugs available for treatment of liver cancer, including sorafenib. As a result, our goal of this research is to highlight the efficacy of nanomedicine-based drug delivery system to enhance drug's cancer-fighting properties. Because of their magnetic properties, certain nanoparticle materials can be employed as a carrier for the medicine to the exact place where the cancer is located. This can lower the amount of the drug that is administered with no impact on the normal cells.
(© 2023. The Author(s).)
Databáze: MEDLINE
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