A comprehensive review of human trophoblast fusion models: recent developments and challenges.

Autor: Li X; Department of Bioinformatics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China.; The Joint International Research Laboratory of Reproduction and Development, Ministry of Education, 400016, Chongqing, China., Li ZH; The Joint International Research Laboratory of Reproduction and Development, Ministry of Education, 400016, Chongqing, China.; Medical Laboratory Department, Traditional Chinese Medicine Hospital of Yaan, 625099, Sichuan, China., Wang YX; The Joint International Research Laboratory of Reproduction and Development, Ministry of Education, 400016, Chongqing, China. yxwang@cqmu.edu.cn., Liu TH; Department of Bioinformatics, School of Basic Medical Sciences, Chongqing Medical University, 400016, Chongqing, China. liuth@cqmu.edu.cn.; The Joint International Research Laboratory of Reproduction and Development, Ministry of Education, 400016, Chongqing, China. liuth@cqmu.edu.cn.
Jazyk: angličtina
Zdroj: Cell death discovery [Cell Death Discov] 2023 Oct 10; Vol. 9 (1), pp. 372. Date of Electronic Publication: 2023 Oct 10.
DOI: 10.1038/s41420-023-01670-0
Abstrakt: As an essential component of the maternal-fetal interface, the placental syncytiotrophoblast layer contributes to a successful pregnancy by secreting hormones necessary for pregnancy, transporting nutrients, mediating gas exchange, balancing immune tolerance, and resisting pathogen infection. Notably, the deficiency in mononuclear trophoblast cells fusing into multinucleated syncytiotrophoblast has been linked to adverse pregnancy outcomes, such as preeclampsia, fetal growth restriction, preterm birth, and stillbirth. Despite the availability of many models for the study of trophoblast fusion, there exists a notable disparity from the ideal model, limiting the deeper exploration into the placental development. Here, we reviewed the existing models employed for the investigation of human trophoblast fusion from several aspects, including the development history, latest progress, advantages, disadvantages, scope of application, and challenges. The literature searched covers the monolayer cell lines, primary human trophoblast, placental explants, human trophoblast stem cells, human pluripotent stem cells, three-dimensional cell spheres, organoids, and placenta-on-a-chip from 1938 to 2023. These diverse models have significantly enhanced our comprehension of placental development regulation and the underlying mechanisms of placental-related disorders. Through this review, our objective is to provide readers with a thorough understanding of the existing trophoblast fusion models, making it easier to select most suitable models to address specific experimental requirements or scientific inquiries. Establishment and application of the existing human placental trophoblast fusion models.
(© 2023. Cell Death Differentiation Association (ADMC).)
Databáze: MEDLINE
Externí odkaz: