The medial septum controls hippocampal supra-theta oscillations.

Autor: Király B; Lendület Laboratory of Systems Neuroscience, Institute of Experimental Medicine, Budapest, Hungary.; Department of Biological Physics, Institute of Physics, Eötvös Loránd University, Budapest, Hungary., Domonkos A; Subcortical Modulation Research Group, Institute of Experimental Medicine, Budapest, Hungary., Jelitai M; Subcortical Modulation Research Group, Institute of Experimental Medicine, Budapest, Hungary., Lopes-Dos-Santos V; Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Martínez-Bellver S; Lendület Laboratory of Systems Neuroscience, Institute of Experimental Medicine, Budapest, Hungary.; Department of Anatomy and Human Embryology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain., Kocsis B; Lendület Laboratory of Systems Neuroscience, Institute of Experimental Medicine, Budapest, Hungary.; Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary., Schlingloff D; Lendület Laboratory of Systems Neuroscience, Institute of Experimental Medicine, Budapest, Hungary., Joshi A; Department of Pharmacology, University of Oxford, Oxford, UK., Salib M; Department of Pharmacology, University of Oxford, Oxford, UK., Fiáth R; Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary.; Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Budapest, Hungary., Barthó P; Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Budapest, Hungary., Ulbert I; Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary.; Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Budapest, Hungary., Freund TF; Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine, Budapest, Hungary., Viney TJ; Department of Pharmacology, University of Oxford, Oxford, UK., Dupret D; Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Varga V; Subcortical Modulation Research Group, Institute of Experimental Medicine, Budapest, Hungary., Hangya B; Lendület Laboratory of Systems Neuroscience, Institute of Experimental Medicine, Budapest, Hungary. hangya.balazs@koki.hu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Oct 10; Vol. 14 (1), pp. 6159. Date of Electronic Publication: 2023 Oct 10.
DOI: 10.1038/s41467-023-41746-0
Abstrakt: Hippocampal theta oscillations orchestrate faster beta-to-gamma oscillations facilitating the segmentation of neural representations during navigation and episodic memory. Supra-theta rhythms of hippocampal CA1 are coordinated by local interactions as well as inputs from the entorhinal cortex (EC) and CA3 inputs. However, theta-nested gamma-band activity in the medial septum (MS) suggests that the MS may control supra-theta CA1 oscillations. To address this, we performed multi-electrode recordings of MS and CA1 activity in rodents and found that MS neuron firing showed strong phase-coupling to theta-nested supra-theta episodes and predicted changes in CA1 beta-to-gamma oscillations on a cycle-by-cycle basis. Unique coupling patterns of anatomically defined MS cell types suggested that indirect MS-to-CA1 pathways via the EC and CA3 mediate distinct CA1 gamma-band oscillations. Optogenetic activation of MS parvalbumin-expressing neurons elicited theta-nested beta-to-gamma oscillations in CA1. Thus, the MS orchestrates hippocampal network activity at multiple temporal scales to mediate memory encoding and retrieval.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
Externí odkaz: