Direct cortical inputs to hippocampal area CA1 transmit complementary signals for goal-directed navigation.
| Autor: | Bowler JC; Department of Neuroscience, Columbia University, New York, NY 10027, USA; Doctoral Program in Neurobiology and Behavior, Columbia University, New York, NY 10027, USA. Electronic address: jcb2238@columbia.edu., Losonczy A; Department of Neuroscience, Columbia University, New York, NY 10027, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA. Electronic address: al2856@columbia.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Neuron [Neuron] 2023 Dec 20; Vol. 111 (24), pp. 4071-4085.e6. Date of Electronic Publication: 2023 Oct 09. |
| DOI: | 10.1016/j.neuron.2023.09.013 |
| Abstrakt: | The subregions of the entorhinal cortex (EC) are conventionally thought to compute dichotomous representations for spatial processing, with the medial EC (MEC) providing a global spatial map and the lateral EC (LEC) encoding specific sensory details of experience. Yet, little is known about the specific types of information EC transmits downstream to the hippocampus. Here, we exploit in vivo sub-cellular imaging to record from EC axons in CA1 while mice perform navigational tasks in virtual reality (VR). We uncover distinct yet overlapping representations of task, location, and context in both MEC and LEC axons. MEC transmitted highly location- and context-specific codes; LEC inputs were biased by ongoing navigational goals. However, during tasks with reliable reward locations, the animals' position could be accurately decoded from either subregion. Our results revise the prevailing dogma about EC information processing, revealing novel ways spatial and non-spatial information is routed and combined upstream of the hippocampus. Competing Interests: Declaration of interests The authors declare no competing interests. (Published by Elsevier Inc.) |
| Databáze: | MEDLINE |
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