The deleterious effects of maternal protein deprivation on the brainstem are minimized with moderate physical activity by offspring during early life.

Autor:	Bernardo EM; Biochemistry and Physiology Graduate Program, Federal University of Pernambuco, Recife, PE, Brazil., Pedroza AAS; Biochemistry and Physiology Graduate Program, Federal University of Pernambuco, Recife, PE, Brazil., Ferreira DJS; Physical Education Department, Federal University of São Francisco Valley, Petrolina, Brazil., de Andrade SC; Neuropsyquiatry and Behavioral Science Graduate Program, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil., Rozendo A; Laboratory of Biochemistry and Exercise Biochemistry/CAV, Federal University of Pernambuco, Vitoria de Santo Antao, PE, Brazil., Fernandes MSS; Neuropsyquiatry and Behavioral Science Graduate Program, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil., Silva TL; Neuropsyquiatry and Behavioral Science Graduate Program, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil., Fernandes MP; Laboratory of Biochemistry and Exercise Biochemistry/CAV, Federal University of Pernambuco, Vitoria de Santo Antao, PE, Brazil., Lagranha CJ; Biochemistry and Physiology Graduate Program, Federal University of Pernambuco, Recife, PE, Brazil.; Neuropsyquiatry and Behavioral Science Graduate Program, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil.; Laboratory of Biochemistry and Exercise Biochemistry/CAV, Federal University of Pernambuco, Vitoria de Santo Antao, PE, Brazil.
Jazyk:	angličtina
Zdroj:	Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme [Appl Physiol Nutr Metab] 2024 Feb 01; Vol. 49 (2), pp. 157-166. Date of Electronic Publication: 2023 Oct 10.
DOI:	10.1139/apnm-2023-0122
Abstrakt:	Maternal protein malnutrition during developmental periods might impair the redox state and the brain's excitatory/inhibitory neural network, increasing central sympathetic tone. Conversely, moderate physical exercise at an early age reduces the risk of chronic diseases. Thus, we hypothesized that a moderate training protocol could reduce the harmful effects of a low-protein maternal diet on the brainstem of young male offspring. We used a rat model of maternal protein restriction during the gestational and lactation period followed by an offspring's continuous treadmill exercise. Pregnant rats were divided into two groups according to the protein content in the diet: normoprotein (NP), receiving 17% of casein, and low protein (LP), receiving 8% of casein until the end of lactation. At 30 days of age, the male offspring were further subdivided into sedentary (NP-Sed and LP-Sed) or exercised (NP-Ex and LP-Ex) groups. Treadmill exercise was performed as follows: 4 weeks, 5 days/week, 60 min/day at 50% of maximal running capacity. The trained animals performed a treadmill exercise at 50% of the maximal running capacity, 60 min/day, 5 days/week, for 4 weeks. Our results indicate that a low-protein diet promotes deficits in the antioxidant system and a likely mitochondrial uncoupling. On the other hand, physical exercise restores the redox balance, which leads to decreased oxidative stress caused by the diet. In addition, it also promotes benefits to GABAergic inhibitory signaling. We conclude that regular moderate physical exercise performed in youthhood protects the brainstem against changes induced by maternal protein restriction. Competing Interests: The authors report there are no competing interests to declare.
Databáze:	MEDLINE
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