High recurrence rate of eczema herpeticum in moderate/severe atopic dermatitis -TREATgermany registry analysis.

Autor: Traidl S; Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.; Hannover Medical School, Cluster of Excellence RESIST (EXC 2155), Hannover, Germany., Heinrich L; Center for Evidence-Based Healthcare, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany., Siegels D; Center for Evidence-Based Healthcare, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany., Rösner L; Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.; Hannover Medical School, Cluster of Excellence RESIST (EXC 2155), Hannover, Germany., Haufe E; Center for Evidence-Based Healthcare, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany., Harder I; Center for Inflammatory Skin Diseases, Department of Dermatology and Allergy, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany., Abraham S; Department of Dermatology, University Allergy Center, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany., Ertner K; Practice Dr. med. Konstantin Ertner, Nuernberg, Germany., Kleinheinz A; Clinics for Dermatology, Elbe Klinikum Buxtehude, Buxtehude, Germany., Schäkel K; Department of Dermatology, University Hospital, Heidelberg, Germany., Wollenberg A; Department of Dermatology and Allergy, University Hospital Augsburg, Augsburg, Ludwig Maximilian University, Munich, Germany., Effendy I; Department of Dermatology, OWL University Hospital of Bielefeld University, Campus Clinic Bielefeld, Bielefeld, Germany., Quist S; Dermatology Clinic, Helix Medical Ecellence Center Mainz, Mainz, Germany., Asmussen A; Practice Dr. med. Andrea Asmussen, Dermatology at Lesum, Bremen, Germany., Wildberger J; Practice Dr. med. Julia Wildberger Hautmedizin, Bad Soden, Germany., Weisshaar E; Division of Occupational Dermatology, Department of Dermatology, Ruprecht-Karls University Heidelberg, Heidelberg, Germany., Wiemers F; Practice Dr. med. Franca Wiemers, Leipzig, Germany., Brücher JJ; Practice Dr. med. Jens-Joachim Brücher, Hautambulatorium Magdeburg, Magdeburg, Germany., Weidinger S; Center for Inflammatory Skin Diseases, Department of Dermatology and Allergy, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany., Schmitt J; Center for Evidence-Based Healthcare, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany., Werfel T; Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.; Hannover Medical School, Cluster of Excellence RESIST (EXC 2155), Hannover, Germany.
Jazyk: angličtina
Zdroj: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG [J Dtsch Dermatol Ges] 2023 Dec; Vol. 21 (12), pp. 1490-1498. Date of Electronic Publication: 2023 Oct 09.
DOI: 10.1111/ddg.15205
Abstrakt: Background: Eczema herpeticum (EH) is a disseminated skin infection caused by herpes simplex virus in atopic dermatitis (AD) patients. The frequency of EH and the clinical features of EH patients have not yet been investigated in a larger cohort.
Methods: We sought to investigate the TREATgermany cohort, a multicenter, non-interventional clinical registry of moderately to severely affected AD patients in Germany. Baseline characteristics of patients included between December 2017 and April 2021 were compared between patients without, single, and multiple EH.
Results: Of the 893 patients, 195 (21.8%) had at least one EH. Of the 195 patients with EH, 107 had multiple EH (54.9%), representing 12.0% of the total study population. While there were no differences in demographic characteristics, previous treatment, and disease scores at enrollment (itch, IGA, oSCORAD, EASI), patients with EH had more frequent atopic comorbidities and sensitizations to house dust mite, food, and mold.
Discussion: TREATgermany registry data suggest a high prevalence and recurrence rate of EH, while there appears to be no specific clinical phenotype, besides an increase in allergies, to identify EH patients in the daily routine.
(© 2023 The Authors. Journal der Deutschen Dermatologischen Gesellschaft published by John Wiley & Sons Ltd on behalf of Deutsche Dermatologische Gesellschaft.)
Databáze: MEDLINE
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