Connecting memory and functional brain networks in older adults: a resting-state fMRI study.

Autor: Waner JL; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, PO Box 100196, 1249 Center Drive, Gainesville, FL, 32610-0165, USA.; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA., Hausman HK; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, PO Box 100196, 1249 Center Drive, Gainesville, FL, 32610-0165, USA.; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA., Kraft JN; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, PO Box 100196, 1249 Center Drive, Gainesville, FL, 32610-0165, USA.; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA., Hardcastle C; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, PO Box 100196, 1249 Center Drive, Gainesville, FL, 32610-0165, USA.; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA., Evangelista ND; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, PO Box 100196, 1249 Center Drive, Gainesville, FL, 32610-0165, USA.; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA., O'Shea A; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, PO Box 100196, 1249 Center Drive, Gainesville, FL, 32610-0165, USA., Albizu A; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, PO Box 100196, 1249 Center Drive, Gainesville, FL, 32610-0165, USA.; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA., Boutzoukas EM; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, PO Box 100196, 1249 Center Drive, Gainesville, FL, 32610-0165, USA.; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA., Van Etten EJ; Department of Psychology and Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA., Bharadwaj PK; Department of Psychology and Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA., Song H; Department of Psychology and Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA., Smith SG; Department of Psychology and Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA., DeKosky ST; Department of Neurology and McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Hishaw GA; Department of Psychiatry, College of Medicine, University of Arizona, Tucson, AZ, USA.; Department of Neurology, College of Medicine, University of Arizona, Tucson, AZ, USA., Wu SS; Department of Biostatistics, College of Public Health and Health Professions, College of Medicine, University of Florida, Gainesville, FL, USA., Marsiske M; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, PO Box 100196, 1249 Center Drive, Gainesville, FL, 32610-0165, USA.; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA., Cohen R; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, PO Box 100196, 1249 Center Drive, Gainesville, FL, 32610-0165, USA.; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA., Alexander GE; Department of Psychology and Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA.; Department of Psychiatry, Neuroscience and Physiological Sciences Graduate Interdisciplinary Programs, and BIO5 Institute, University of Arizona and Arizona Alzheimer's Disease Consortium, Tucson, AZ, USA., Porges EC; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, PO Box 100196, 1249 Center Drive, Gainesville, FL, 32610-0165, USA.; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA., Woods AJ; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, PO Box 100196, 1249 Center Drive, Gainesville, FL, 32610-0165, USA. ajwoods@phhp.ufl.edu.; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA. ajwoods@phhp.ufl.edu.; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA. ajwoods@phhp.ufl.edu.
Jazyk: angličtina
Zdroj: GeroScience [Geroscience] 2023 Oct; Vol. 45 (5), pp. 3079-3093. Date of Electronic Publication: 2023 Oct 10.
DOI: 10.1007/s11357-023-00967-3
Abstrakt: Limited research exists on the association between resting-state functional network connectivity in the brain and learning and memory processes in advanced age. This study examined within-network connectivity of cingulo-opercular (CON), frontoparietal control (FPCN), and default mode (DMN) networks, and verbal and visuospatial learning and memory in older adults. Across domains, we hypothesized that greater CON and FPCN connectivity would associate with better learning, and greater DMN connectivity would associate with better memory. A total of 330 healthy older adults (age range = 65-89) underwent resting-state fMRI and completed the Hopkins Verbal Learning Test-Revised (HVLT-R) and Brief Visuospatial Memory Test-Revised (BVMT-R) in a randomized clinical trial. Total and delayed recall scores were assessed from baseline data, and a learning ratio calculation was applied to participants' scores. Average CON, FPCN, and DMN connectivity values were obtained with CONN Toolbox. Hierarchical regressions controlled for sex, race, ethnicity, years of education, and scanner site, as this was a multi-site study. Greater within-network CON connectivity was associated with better verbal learning (HVLT-R Total Recall, Learning Ratio), visuospatial learning (BVMT-R Total Recall), and visuospatial memory (BVMT-R Delayed Recall). Greater FPCN connectivity was associated with better visuospatial learning (BVMT-R Learning Ratio) but did not survive multiple comparison correction. DMN connectivity was not associated with these measures of learning and memory. CON may make small but unique contributions to learning and memory across domains, making it a valuable target in future longitudinal studies and interventions to attenuate memory decline. Further research is necessary to understand the role of FPCN in learning and memory.
(© 2023. The Author(s), under exclusive licence to American Aging Association.)
Databáze: MEDLINE
Externí odkaz: