Structural and functional diversity of type IV secretion systems.

Autor: Costa TRD; Centre for Bacterial Resistance Biology, Department of Life Sciences, Imperial College, London, UK. t.costa@imperial.ac.uk., Patkowski JB; Centre for Bacterial Resistance Biology, Department of Life Sciences, Imperial College, London, UK., Macé K; Institute of Structural and Molecular Biology, Birkbeck and UCL, London, UK.; Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes and CNRS, Rennes, France., Christie PJ; Department of Microbiology and Molecular Genetics, McGovern Medical School at UTHealth, Houston, TX, USA. peter.j.christie@uth.tmc.edu., Waksman G; Institute of Structural and Molecular Biology, Birkbeck and UCL, London, UK. g.waksman@bbk.ac.uk.
Jazyk: angličtina
Zdroj: Nature reviews. Microbiology [Nat Rev Microbiol] 2024 Mar; Vol. 22 (3), pp. 170-185. Date of Electronic Publication: 2023 Oct 09.
DOI: 10.1038/s41579-023-00974-3
Abstrakt: Considerable progress has been made in recent years in the structural and molecular biology of type IV secretion systems in Gram-negative bacteria. The latest advances have substantially improved our understanding of the mechanisms underlying the recruitment and delivery of DNA and protein substrates to the extracellular environment or target cells. In this Review, we aim to summarize these exciting structural and molecular biology findings and to discuss their functional implications for substrate recognition, recruitment and translocation, as well as the biogenesis of extracellular pili. We also describe adaptations necessary for deploying a breadth of processes, such as bacterial survival, host-pathogen interactions and biotic and abiotic adhesion. We highlight the functional and structural diversity that allows this extremely versatile secretion superfamily to function under different environmental conditions and in different bacterial species. Additionally, we emphasize the importance of further understanding the mechanism of type IV secretion, which will support us in combating antimicrobial resistance and treating type IV secretion system-related infections.
(© 2023. Crown.)
Databáze: MEDLINE
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