Reassessment After Locoregional Treatment of Hepatocellular Carcinoma Previous Liver Transplantation: Is MRI Necessary for All Patients?

Autor: Chairi MHM; Department of Surgery, Virgen de las Nieves University Hospital, Granada, Spain. Electronic address: Yasinmc1994@gmail.com., Arias ABV; Transplant Surgery Division, Department of Surgery, Virgen de las Nieves University Hospital, Granada, Spain., Zurbano MS; Department of Surgery, Virgen de las Nieves University Hospital, Granada, Spain., Ríos PD; Department of Surgery, Virgen de las Nieves University Hospital, Granada, Spain., Herrera MTV; Transplant Surgery Division, Department of Surgery, Virgen de las Nieves University Hospital, Granada, Spain., Del Moral JMV; Transplant Surgery Division, Department of Surgery, Virgen de las Nieves University Hospital, Granada, Spain.
Jazyk: angličtina
Zdroj: Transplantation proceedings [Transplant Proc] 2023 Dec; Vol. 55 (10), pp. 2275-2277. Date of Electronic Publication: 2023 Oct 08.
DOI: 10.1016/j.transproceed.2023.08.032
Abstrakt: Background: The tumor response of cirrhotic patients with hepatocellular carcinoma (HCC) undergoing locoregional treatment (TLR) before liver transplantation can be evaluated using different imaging tests. The aim of this study was to compare the correlation of radiological response evaluated by magnetic resonance imaging (MRI) vs computed tomography (CT) vs ultrasound with histopathological findings.
Methods: A retrospective single-center study was performed. Data of patients undergoing Liver transplantation due to HCC between January 2010 and December were collected, selecting patients who underwent TLR.
Results: Four hundred and four patients were transplanted, of whom 103 (25.5%) had HCC. Ninety-seven patients (93.2%) received TLR. Eighty-eight of these patients (90.7%) underwent a reevaluation imaging test: 8 (8.2%) underwent ultrasound, 68 (70.1%) underwent MRI, and 12 (12.4%) underwent CT. Of the 88 patients, 59% were classified as nonviable LR-TR (Liver Imaging Reporting and Data System Treatment Response), 32.5% as viable LR-TR, and the rest (8.5%) as equivocal LR-TR. Regarding the correlation of the degree of radiological response according to each imaging test, ultrasound categorized 62.5% as nonviable LR-TR vs 60.6% by MRI vs 44.4% by CT, with these differences not being significant (P = .779). Regarding the correlation of patients classified as nonviable LR-TR by each test and total tumor necrosis in histopathology, both MRI and ultrasound correctly classified 60% of complete necrosis as nonviable LR-TR, and in the case of CT, it was 50%, with these differences not being significant (P = 1).
Conclusion: Ultrasound and CT have obtained similar results as reevaluation tests to MRI, which could replace it in case of unavailability of the latter.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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