SARS-CoV-2 variants of concern in children and adolescents with COVID-19: a systematic review.

Autor:	Wiedenmann M; Medical Service Unit, Swiss Tropical and Public Health Institute, Basel, Switzerland margarethe.wiedenmann@swisstph.ch.; University of Basel, Basel, Switzerland., Ipekci AM; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland., Araujo-Chaveron L; EHESP French School of Public Health, Rennes, France.; Emerging Disease Epidemiology Unit, Insitut Pasteur, Paris, France., Prajapati N; Université Paris-Saclay, Gif-sur-Yvette, France.; Exposome and Heredity Team, Institut national de la santé et de la recherche médicale, Paris, France., Lam YT; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland., Alam MI; EHESP Rennes-Sorbonne Paris Cité, Rennes, France., L'Huillier AG; Département de pédiatrie, gynécologie et obstétrique, HUG, Geneve, Switzerland., Zhelyazkov I; The University of Sheffield, Sheffield, UK., Heron L; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland., Low N; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland., Goutaki M; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2023 Oct 09; Vol. 13 (10), pp. e072280. Date of Electronic Publication: 2023 Oct 09.
DOI:	10.1136/bmjopen-2023-072280
Abstrakt:	Objectives: Infections by SARS-CoV-2 variants of concern (VOCs) might affect children and adolescents differently than earlier viral lineages. We aimed to address five questions about SARS-CoV-2 VOC infections in children and adolescents: (1) symptoms and severity, (2) risk factors for severe disease, (3) the risk of infection, (4) the risk of transmission and (5) long-term consequences following a VOC infection. Design: Systematic review. Data Sources: The COVID-19 Open Access Project database was searched up to 1 March 2022 and PubMed was searched up to 9 May 2022. Eligibility Criteria: We included observational studies about Alpha, Beta, Gamma, Delta and Omicron VOCs among ≤18-year-olds. We included studies in English, German, French, Greek, Italian, Spanish and Turkish. Data Extraction and Synthesis: Two reviewers extracted and verified the data and assessed the risk of bias. We descriptively synthesised the data and assessed the risks of bias at the outcome level. Results: We included 53 articles. Most children with any VOC infection presented with mild disease, with more severe disease being described with the Delta or the Gamma VOC. Diabetes and obesity were reported as risk factors for severe disease during the whole pandemic period. The risk of becoming infected with a SARS-CoV-2 VOC seemed to increase with age, while in daycare settings the risk of onward transmission of VOCs was higher for younger than older children or partially vaccinated adults. Long-term symptoms following an infection with a VOC were described in <5% of children and adolescents. Conclusion: Overall patterns of SARS-CoV-2 VOC infections in children and adolescents are similar to those of earlier lineages. Comparisons between different pandemic periods, countries and age groups should be improved with complete reporting of relevant contextual factors, including VOCs, vaccination status of study participants and the risk of exposure of the population to SARS-CoV-2. Prospero Registration Number: CRD42022295207. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ.)
Databáze:	MEDLINE
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