Serum alarmins and the risk of incident interstitial lung disease in rheumatoid arthritis.

Autor:	Poole JA; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA., England BR; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.; Veterans Affairs (VA) Nebraska-Western Iowa Health Care System, Omaha, NE, USA., Sayles H; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA., Johnson TM; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.; Veterans Affairs (VA) Nebraska-Western Iowa Health Care System, Omaha, NE, USA., Duryee MJ; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.; Veterans Affairs (VA) Nebraska-Western Iowa Health Care System, Omaha, NE, USA., Hunter CD; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.; Veterans Affairs (VA) Nebraska-Western Iowa Health Care System, Omaha, NE, USA., Baker JF; Corporal Michael J. Crescenz Veterans Affairs Medical Center, School of Medicine and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA., Kerr GS; Washington, D.C. VA, Georgetown and Howard University, Washington, DC, USA., Kunkel G; George E. Wahlen Veterans Affairs Medical Center, University of Utah, Salt Lake City, UT, USA., Cannon GW; George E. Wahlen Veterans Affairs Medical Center, University of Utah, Salt Lake City, UT, USA., Sauer BC; George E. Wahlen Veterans Affairs Medical Center, University of Utah, Salt Lake City, UT, USA., Wysham KD; VA Puget Sound Health Care System, University of Washington, Seattle, WA, USA., Joseph AM; VA St. Louis Health Care System, Washington University School of Medicine, St Louis, MO, USA., Wallace BI; VA Ann Arbor Healthcare System, University of Michigan Medical School, Ann Arbor, MI, USA., Thiele GM; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.; Veterans Affairs (VA) Nebraska-Western Iowa Health Care System, Omaha, NE, USA., Mikuls TR; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.; Veterans Affairs (VA) Nebraska-Western Iowa Health Care System, Omaha, NE, USA.
Jazyk:	angličtina
Zdroj:	Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2024 Jul 01; Vol. 63 (7), pp. 1998-2005.
DOI:	10.1093/rheumatology/kead535
Abstrakt:	Objectives: To quantify associations of serum alarmins with risk of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Methods: Using serum collected at enrolment, three alarmins (IL-33, thymic stromal lymphopoietin [TSLP] and IL-25) were measured in a multicentre prospective RA cohort. ILD was classified using systematic medical record review. Cross-sectional associations of log-transformed (IL-33, TSLP) or quartile (IL-25) values with RA-ILD at enrolment (prevalent RA-ILD) were examined using logistic regression, while associations with incident RA-ILD developing after enrolment were examined using Cox proportional hazards. Covariates in multivariate models included age, sex, race, smoking status, RA disease activity score and anti-cyclic citrullinated antibody positivity. Results: Of 2835 study participants, 115 participants (4.1%) had prevalent RA-ILD at baseline and an additional 146 (5.1%) developed incident ILD. There were no associations between serum alarmin concentrations and prevalent ILD in unadjusted or adjusted logistic regression models. In contrast, there was a significant inverse association between IL-33 concentration and the risk of developing incident RA-ILD in unadjusted (hazard ratio [HR] 0.73 per log-fold increase; 95% CI: 0.57, 0.95; P = 0.018) and adjusted (HR 0.77; 95% CI: 0.59, 1.00; P = 0.047) models. No significant associations of TSLP or IL-25 with incident ILD were observed. Conclusion: In this study, we observed a significant inverse association between serum IL-33 concentration and the risk of developing incident RA-ILD, but no associations with prevalent ILD. Additional investigation is required to better understand the mechanisms driving this relationship and how serum alarmin IL-33 assessment might contribute to clinical risk stratification in patients with RA. (© The Author(s) 2023. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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