Prognostic value of C-reactive protein-to-albumin ratio in acute pancreatitis: a systematic review and meta-analysis.

Autor:	Mariadi IK; Division of Gastroenterology and Hepatology, Faculty of Medicine, Udayana University/Prof Dr. I.G.N.G. Ngoerah Hospital, Denpasar, Bali, Indonesia., Somayana G; Division of Gastroenterology and Hepatology, Faculty of Medicine, Udayana University/Prof Dr. I.G.N.G. Ngoerah Hospital, Denpasar, Bali, Indonesia., Shalim CP; Siloam Hospitals Kebon Jeruk, West Jakarta, Jakarta, Indonesia., Sindhughosa DA; Division of Gastroenterology and Hepatology, Faculty of Medicine, Udayana University/Prof Dr. I.G.N.G. Ngoerah Hospital, Denpasar, Bali, Indonesia., Daniella D; Department of Internal Medicine, Faculty of Medicine, Udayana University/Prof Dr. I.G.N.G. Ngoerah Hospital, Denpasar, Bali, Indonesia., Purwanta MLA; Intern Doctor, Internal Medicine Department, Bali Mandara Hospital, Denpasar, Bali, Indonesia.
Jazyk:	angličtina
Zdroj:	F1000Research [F1000Res] 2023 Sep 22; Vol. 12, pp. 748. Date of Electronic Publication: 2023 Sep 22 (Print Publication: 2023).
DOI:	10.12688/f1000research.134938.2
Abstrakt:	Background : Acute pancreatitis (AP) is a common disorder and although most of the cases are mild, the mortality risk is high when it comes to severe AP. It is therefore important to determine the severity of AP as early as possible. This review aimed to determine the prognostic value of C-reactive protein-to-albumin ratio (CRP/alb ratio) in patients with AP. Methods : We performed a systematic search on the electronic databases PubMed, Science Direct, and Cochrane Library up to January 2023. Studies reporting CRP/alb ratio on admission and its association with severity or mortality in AP patients were included. We calculated pooled mean difference (MD) and their 95% confidence intervals (CI) using a random-effects model. Quality assessment of the included studies was appraised using a Newcastle-Ottawa scale. Results : A total of six studies comprising 2244 patients were included in this meta-analysis. Severe AP had higher CRP/alb ratio on admission than mild-moderate AP (pooled MD: 3.59; 95% CI: 2.51-4.68; p<0.00001). CRP/alb ratio was also significantly higher on non-survivor AP patients compared to survivor AP patients (pooled MD: 2.12; 95% CI: 0.43-3.8; p < 0.01). Conclusion : High CRP/alb ratio can be used as an early predictor of poor prognosis in patients with AP. Competing Interests: No competing interests were disclosed. (Copyright: © 2023 Mariadi IK et al.)
Databáze:	MEDLINE
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