Prevalence of acute myeloid leukemia and its associated risk factors at a tertiary care center: a retrospective cross-sectional study.

Autor:	Chaurasiya PS; Department of Internal Medicine, Kalaiya Provincial Hospital, Bara., Lamsal DK; Department of Internal Medicine, Civil Service Hospital., Khatri A; Department of Internal Medicine, Civil Service Hospital., Parajuli A; Department of Internal Medicine, Civil Service Hospital., Shrestha PR; Department of Internal Medicine, Civil Service Hospital., Aryal L; Department of Internal Medicine, Burtibang Primary Health Care Center, Baglung, Nepal., Pokhrel S; Department of Internal Medicine, Civil Service Hospital., Gurung S; Department of Emergency Medicine, Shivanagar Primary Health Care Center, Chitwan., Karki S; Department of Emergency Medicine, Military Hospital Itahari, Sunsari., Khadka M; Nepalese Army Institute of Health Sciences, Kathmandu, Nepal.
Jazyk:	angličtina
Zdroj:	Annals of medicine and surgery (2012) [Ann Med Surg (Lond)] 2023 Aug 14; Vol. 85 (10), pp. 4794-4798. Date of Electronic Publication: 2023 Aug 14 (Print Publication: 2023).
DOI:	10.1097/MS9.0000000000001189
Abstrakt:	Background: Acute myeloid leukemia (AML) is a common malignant disorder of the bone marrow, accounting for 23.1% of total leukemia cases globally in 2017. This study aimed to know the prevalence of AML in a tertiary hospital center in Nepal and assess the associated etiological factors in the causation of AML. Materials and Methods: A hospital-based retrospective cross-sectional study was conducted among patients with acute leukemia admitted to a tertiary care center in Kathmandu from 1 April 2021 to 30 April 2022. Three hundred and ten participants with acute leukemia were selected via a convenience sampling technique. The data were entered into Microsoft Excel 365 and then analyzed using Statistical Packages for Social Sciences version 22.0. Results: One hundred and forty five (46.7%) out of 310 acute leukemia patients had AML. Most of the cases were male (104, 71.7%) and aged 40-49 years (36, 24.8%). The most common signs and symptoms were pallor (115, 79.3%), fever ( n =92, 63.4%), and lethargy/weakness (78, 53.8%). Ninety one (62.8%) patients underwent multiple cycles of chemotherapy while 51 (35.2%) had supportive care only, and 3 (2.1%) went bone marrow transplants. Conclusion: The prevalence of AML was higher as compared to AML in other studies done in a similar setting. Early diagnosis and treatment are key to a good prognosis and cure in most cases. Competing Interests: The authors declare that they have no conflicts of interest.Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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