Low Pretreatment Bone Mineral Density in Gender Diverse Youth.

Autor:	Hodax JK; Division of Pediatric Endocrinology, Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington, USA.; University of Washington School of Medicine, Seattle, Washington, USA., Brady C; University of Washington School of Medicine, Seattle, Washington, USA., DiVall S; Division of Pediatric Endocrinology, Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington, USA.; University of Washington School of Medicine, Seattle, Washington, USA., Ahrens KR; University of Washington School of Medicine, Seattle, Washington, USA.; Division of Adolescent Medicine, Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington, USA., Carlin K; Seattle Children's Research Institute, Seattle, Washington, USA., Khalatbari H; University of Washington School of Medicine, Seattle, Washington, USA.; Division of Radiology, Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington, USA., Parisi MT; University of Washington School of Medicine, Seattle, Washington, USA.; Division of Radiology, Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington, USA., Salehi P; Division of Pediatric Endocrinology, Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington, USA.; University of Washington School of Medicine, Seattle, Washington, USA.
Jazyk:	angličtina
Zdroj:	Transgender health [Transgend Health] 2023 Oct 04; Vol. 8 (5), pp. 467-471. Date of Electronic Publication: 2023 Oct 04 (Print Publication: 2023).
DOI:	10.1089/trgh.2021.0183
Abstrakt:	Gender diverse adolescents have low pretreatment bone mineral density (BMD), with variable changes in BMD after initiation of gender-affirming treatment. We aimed to assess factors associated with low BMD in gender diverse youth. Sixty-four patients were included in our analysis (73% assigned male at birth). Subtotal whole-body BMD Z -scores were low in 30% of patients, and total lumbar spine BMD Z -scores low in 14%. There was a positive association with body mass index, and no association with vitamin D level. Male sex assigned at birth was associated with lower pretreatment BMD, with lower average BMD Z -scores compared to previous studies. Competing Interests: P.S. is involved in clinical research funded by Soleno Therapeutics, Inc., and Millendo Therapeutics, Inc. The other authors have no conflicts of interest to disclose. (Copyright 2023, Mary Ann Liebert, Inc., publishers.)
Databáze:	MEDLINE
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