Haematopoietic Stem Cell Transplant Trends in Pakistan: Activity Survey from Pakistan Bone Marrow Transplant Group.

Autor: Ali N; Aga Khan University, Karachi, Pakistan., Iftikhar R; Armed Forces Bone Marrow Transplant Center, Rawalpindi, Pakistan., Ayaz Mir M; Shifa International Hospital, Islamabad, Pakistan., Bokhari SW; Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan., Rehman JU; Armed Forces Bone Marrow Transplant Center, Rawalpindi, Pakistan., Zaidi U; National Institute of Blood Diseases, Karachi, Pakistan., Nasir S; Quaid-e-Azam International Hospital, Islamabad, Pakistan., Adil SN; Aga Khan University, Karachi, Pakistan., Satti T; Shifa International Hospital, Islamabad, Pakistan., Nisa Chaudhry QU; Armed Forces Bone Marrow Transplant Center, Rawalpindi, Pakistan., Farhan M; Gambat Institute of Medical Sciences, Gambat, Pakistan., Farzana T; The Children's Hospital Lahore, Lahore, Pakistan., Ghafoor T; Armed Forces Bone Marrow Transplant Center, Rawalpindi, Pakistan., Ahsan B; Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan., Khan AS; Shifa International Hospital, Islamabad, Pakistan., Khan FA; Dow University of Health Sciences, Karachi, Pakistan., Fatima SI; Pakistan Institute of Medical Sciences, Islamabad, Pakistan., Samad SA; National Institute of Blood Diseases, Karachi, Pakistan., Batool A; Akbar Niazi Teaching Hospital, Islamabad, Pakistan., Nadeem HM; Gambat Institute of Medical Sciences, Gambat, Pakistan., Abbas Bukhari SN; The Children's Hospital Lahore, Lahore, Pakistan., Ansari SH; Children's Hospital Karachi, Karachi, Pakistan., Ahmed P; Quaid-e-Azam International Hospital, Islamabad, Pakistan.; Gambat Institute of Medical Sciences, Gambat, Pakistan.
Jazyk: angličtina
Zdroj: Journal of transplantation [J Transplant] 2023 Sep 28; Vol. 2023, pp. 8865364. Date of Electronic Publication: 2023 Sep 28 (Print Publication: 2023).
DOI: 10.1155/2023/8865364
Abstrakt: Pakistan is the fifth most populous country with a population of 225 million and has health expenditure accounting for only 2.8 percent of gross domestic product (GDP). Accordingly, there are a limited number of haematology-oncology and transplant centers in the country. The Pakistan Blood and Marrow Transplant (PBMT) group was established in 2020, and this report is the first activity survey from January 2021 to December 2022 focusing on the trends of matched-related donor, haploidentical, and autologous transplants in a developing country. A total of 12 transplant centers contributed data on the modified PBMT survey form retrospectively and 806 haematopoietic stem cell transplants (HSCTs) were carried out during the study duration. Allogeneic HSCT constituted 595 (73.8%) of all the transplants; this is in stark contrast to Western data, where autologous HSCT accounts for the majority of transplants. ß -thalassemia major and aplastic anemia were the commonest indications for allogeneic HSCT, in contrast to Western data, where acute leukemia is the leading transplant indication. Autologous transplants were more frequently performed for Hodgkin's lymphoma as compared to non-Hodgkin's lymphoma and multiple myeloma. The use of peripheral and bone marrow stem cells was comparable. A myeloablative conditioning regimen was routinely used in patients with acute leukemia. This report provides an insight of HSCT trends in Pakistan which are different from those of Western centers contributing to transplant data from South Asia.
Competing Interests: The authors declare that there are no conflicts of interest.
(Copyright © 2023 Natasha Ali et al.)
Databáze: MEDLINE
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