Cardiac multiscale bioimaging: from nano- through micro- to mesoscales.

Autor: Tolstik E; Department of Cardiovascular Pharmacology, Translational Research, Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V. Bunsen-Kirchhoff-Strasse 11, 44139 Dortmund, Germany. Electronic address: elen.tolstik@isas.de., Lehnart SE; Department of Cardiology and Pneumology, Cellular Biophysics and Translational Cardiology Section, Heart Research Center Göttingen, University Medical Center Göttingen, Georg-August University Göttingen, Robert-Koch-Strasse 42a, 37075 Göttingen, Germany; Cluster of Excellence Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells (MBExC2067), University of Göttingen, 37073 Göttingen, Germany; Collaborative Research Center SFB1190 Compartmental Gates and Contact Sites in Cells, University of Göttingen, 37073 Göttingen, Germany., Soeller C; Department of Physiology, University of Bern, Bühlplatz 5, 3012 Bern, Switzerland., Lorenz K; Department of Cardiovascular Pharmacology, Translational Research, Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V. Bunsen-Kirchhoff-Strasse 11, 44139 Dortmund, Germany; Institute of Pharmacology and Toxicology, University of Würzburg, Versbacher Strasse 9, 97078 Würzburg, Germany., Sacconi L; Institute of Clinical Physiology, National Research Council, Rome, Italy; Institute for Experimental Cardiovascular Medicine, University Freiburg, Elsässer Strasse 2q, 79110 Freiburg, Germany. Electronic address: leonardo.sacconi@cnr.it.
Jazyk: angličtina
Zdroj: Trends in biotechnology [Trends Biotechnol] 2024 Feb; Vol. 42 (2), pp. 212-227. Date of Electronic Publication: 2023 Oct 06.
DOI: 10.1016/j.tibtech.2023.08.007
Abstrakt: Cardiac multiscale bioimaging is an emerging field that aims to provide a comprehensive understanding of the heart and its functions at various levels, from the molecular to the entire organ. It combines both physiologically and clinically relevant dimensions: from nano- and micrometer resolution imaging based on vibrational spectroscopy and high-resolution microscopy to assess molecular processes in cardiac cells and myocardial tissue, to mesoscale structural investigations to improve the understanding of cardiac (patho)physiology. Tailored super-resolution deep microscopy with advanced proteomic methods and hands-on experience are thus strategically combined to improve the quality of cardiovascular research and support future medical decision-making by gaining additional biomolecular information for translational and diagnostic applications.
Competing Interests: Declarations of interest No interests are declared.
(Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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