Accumulated exposure to high non-high-density lipoprotein cholesterol increases the risk of cardiovascular diseases in hypertensive individuals: An 11-year prospective cohort study.

Autor: Wu W; Department of Cardiology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China.; Shantou University Medical College, Shantou, China., Chen Y; Department of Endocrinology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China., Wu K; Department of Cardiology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China.; Shantou University Medical College, Shantou, China., Zheng H; Department of Cardiology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China.; Shantou University Medical College, Shantou, China., Chen G; Cardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Wang X; Shantou University Medical College, Shantou, China., Huang Z; Shantou University Medical College, Shantou, China., Cai Z; Department of Cardiology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China., Cai Z; Department of Cardiology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China.; Shantou University Medical College, Shantou, China., Chen Z; Department of Cardiology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China., Lan Y; Department of Cardiology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China., Chen S; Department of Cardiology, Kailuan General Hospital, Tangshan, China., Wu S; Department of Cardiology, Kailuan General Hospital, Tangshan, China., Chen Y; Department of Cardiology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China.
Jazyk: angličtina
Zdroj: Clinical and experimental hypertension (New York, N.Y. : 1993) [Clin Exp Hypertens] 2023 Dec 31; Vol. 45 (1), pp. 2264540. Date of Electronic Publication: 2023 Oct 08.
DOI: 10.1080/10641963.2023.2264540
Abstrakt: Background: The relationship of cumulative non high-density lipoprotein-cholesterol (Cum-non-HDL-C) concentration with the risk of cardiovascular disease (CVD) in individuals with hypertension remains unclear.
Methods: In total 27 234 participants for whom three consecutive total cholesterol and HDL-C concentrations were available, and who did not have CVD, comprising 13 617 with hypertension and 13 617 without from 2006 to 2010. Participants were placed into four groups according to Cum-non-HDL-C. Cox proportional hazards models were used to evaluate the relationship between Cum-non-HDL-C and the risk of CVD.
Results: Over a median 11 years, 1,298 participants with hypertension developed CVD. After adjustment for multiple potential confounding factors, compared with participants with hypertension and Cum-non-HDL-C < 130 mg/dl, the fully adjusted hazard ratios and 95% confidence intervals of CVD associated with Cum-non-HDL-C values of 130-159 mg/dl, 160-189 mg/dl, and ≥ 190 mg/dl were 1.23 (1.01, 1.34), 1.27 (1.04, 1.56), and 1.51 (1.13, 2.01), respectively. Compared with participants without hypertension and a Cum-non-HDL-C < 130 mg/dl, the fully adjusted hazard ratios (95% confidence intervals) for the participants with hypertension and Cum-non-HDL-Cs < 130 mg/dl, 130-159 mg/dl, 160-189 mg/dl, and ≥ 190 mg/dl were 1.84 (1.55, 2.18), 2.16 (1.81, 2.59), 2.17 (1.73, 2.70), and 2.45 (1.12, 3.29), respectively.
Conclusions: A consistently high non-HDL-C concentration increases the risk of CVD in individuals with hypertension, as does prolonged exposure to a high non-HDL-C concentration. Thus, the achievement of target blood pressure and non-HDL-C concentrations should help reduce the risk of CVD in individuals with hypertension.
Databáze: MEDLINE
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